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Literature summary for 4.1.1.36 extracted from
- 4-Phosphopantetheine biosynthesis in archaea (2006), J. Biol. Chem., 281, 5435-5444.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli strain M15 | Methanocaldococcus jannaschii |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C54A | comparable activity with that of the wild type enzyme | Methanocaldococcus jannaschii |
| C73A | comparable activity with that of the wild type enzyme | Methanocaldococcus jannaschii |
| C94A | comparable activity with that of the wild type enzyme | Methanocaldococcus jannaschii |
| C96A | comparable activity with that of the wild type enzyme | Methanocaldococcus jannaschii |
| E168A | drastically reduced activity | Methanocaldococcus jannaschii |
| E168D | significantly decreased activity | Methanocaldococcus jannaschii |
| E168K | residual activity | Methanocaldococcus jannaschii |
| H139A/E168K | drastically reduced PPC decarboxylase activity | Methanocaldococcus jannaschii |
| H87A | reduced activity | Methanocaldococcus jannaschii |
| H87N | reduced activity | Methanocaldococcus jannaschii |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 24060 | - |
10 * 24060, gel filtration | Methanocaldococcus jannaschii |
| 242000 | - |
gel filtration | Methanocaldococcus jannaschii |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Methanocaldococcus jannaschii | - |
- |
- |
| Methanocaldococcus jannaschii DSM 2661 | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Ni-NTA resin chromatography and Superdex 200 gel filtration | Methanocaldococcus jannaschii |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-[(R)-4'-phosphopantothenoyl]-L-cysteine | - |
Methanocaldococcus jannaschii | pantotheine 4'-phosphate + CO2 | - |
? |  |
| N-[(R)-4'-phosphopantothenoyl]-L-cysteine | - |
Methanocaldococcus jannaschii DSM 2661 | pantotheine 4'-phosphate + CO2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodecamer | 10 * 24060, gel filtration | Methanocaldococcus jannaschii |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CoaC | part of the bifunctional Dfp protein | Methanocaldococcus jannaschii |
| PPC decarboxylase | - |
Methanocaldococcus jannaschii |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| flavin | - |
Methanocaldococcus jannaschii | |
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Release 2023.1 (January 2023)
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