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Literature summary for 4.1.1.35 extracted from

  • Jiang, S.S.; Liu, M.C.; Teng, L.J.; Wang, W.B.; Hsueh, P.R.; Liaw, S.J.
    Proteus mirabilis pmrI, an RppA-regulated gene necessary for polymyxin B resistance, biofilm formation, and urothelial cell invasion (2010), Antimicrob. Agents Chemother., 54, 1564-1571.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli BL21 as His-tagged enzyme Proteus mirabilis

Protein Variants

Protein Variants Comment Organism
additional information by using Tn5 transposon mutagenesis, a gene, PpmrI, is identified which plays important roles in controlling lipopolysaccharides modification, polymyxin B susceptibility, biofilm formation, and cell invasion in Proteus mirabilis. The expression of PpmrI can be induced by polymyxin B via RppA, a response regulator of the bacterial two-component system. Together, these results reveal a mechanism by which Proteus mirabilis regulates polymyxin B resistance and virulence Proteus mirabilis

Organism

Organism UniProt Comment Textmining
Proteus mirabilis C9E3L0
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Proteus mirabilis N2 C9E3L0
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Synonyms

Synonyms Comment Organism
UDP-glucuronic acid decarboxylase
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Proteus mirabilis

Expression

Organism Comment Expression
Proteus mirabilis expression of PpmrI can be induced by polymyxin B via RppA, a response regulator of the bacterial two-component system. Together, these results reveal a mechanism by which Proteus mirabilis regulates polymyxin B resistance and virulence up