Literature summary for 4.1.1.33 extracted from

Rothwell, C.; Lebreton, A.; Young Ng, C.; Lim, J.Y.; Liu, W.; Vasudevan, S.; Labow, M.; Gu, F.; Gaither, L.A.
Cholesterol biosynthesis modulation regulates dengue viral replication (2009), Virology, 389, 8-19.

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Application

Application	Comment	Organism
drug development	siRNAs targeting mevalonate (diphospho) decarboxylase (MVD) are found to inhibit Dengue virus replication in a stable A549 subgenomic Renilla replicon cell line (Rluc-replicon) and in naive A549 cells after dengue type 2 (DEN-2) New Guinea C (NGC) live virus infection, knock down of mevalonate (diphospho) decarboxylase can inhibit dengue viral replication	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + 5-diphosphomevalonate	Homo sapiens	-	ADP + phosphate + isopentenyl diphosphate + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + 5-diphosphomevalonate	-	Homo sapiens	ADP + phosphate + isopentenyl diphosphate + CO2	-	?

Synonyms

Synonyms	Comment	Organism
mevalonate diphospho decarboxylase	-	Homo sapiens
MVD	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	investigation of the role of mevalonate diphospho decarboxylase in viral replication	Homo sapiens

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Release 2023.1 (January 2023)