Application | Comment | Organism |
---|---|---|
pharmacology | the enzyme is an antibiotic target, since inhibition prevents the production of isopentenyl diphosphate | Streptococcus pneumoniae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.001 | - |
(3R)-3-cyclopropyl-3-hydroxy-5-[[hydroxy(phosphonooxy)phosphoryl]oxy]pentanoic acid | - |
Streptococcus pneumoniae | |
0.0012 | - |
diphosphomevalonate | - |
Streptococcus pneumoniae | |
0.0015 | - |
(3R)-3-ethyl-3-hydroxy-5-[[hydroxy(phosphonooxy)phosphoryl]oxy]pentanoic acid | - |
Streptococcus pneumoniae | |
0.0017 | - |
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)pent-4-enoic acid | - |
Streptococcus pneumoniae | |
0.0028 | - |
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)hex-5-enoic acid | - |
Streptococcus pneumoniae | |
0.0029 | - |
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)pent-4-ynoic acid | - |
Streptococcus pneumoniae | |
0.0063 | - |
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)hex-4-ynoic acid | - |
Streptococcus pneumoniae | |
0.016 | - |
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)-4-methylpentanoic acid | - |
Streptococcus pneumoniae | |
0.029 | - |
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)-5-methylhexanoic acid | - |
Streptococcus pneumoniae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus pneumoniae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(3R)-3-cyclopropyl-3-hydroxy-5-[[hydroxy(phosphonooxy)phosphoryl]oxy]pentanoic acid + ATP | - |
Streptococcus pneumoniae | ? | - |
? | |
(3R)-3-ethyl-3-hydroxy-5-[[hydroxy(phosphonooxy)phosphoryl]oxy]pentanoic acid + ATP | - |
Streptococcus pneumoniae | ? | - |
? | |
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)-4-methylpent-4-enoic acid + ATP | - |
Streptococcus pneumoniae | ? | - |
? | |
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)-4-methylpentanoic acid + ATP | - |
Streptococcus pneumoniae | ? | - |
? | |
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)-5-methylhexanoic acid + ATP | - |
Streptococcus pneumoniae | ? | - |
? | |
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)heptanoic acid + ATP | - |
Streptococcus pneumoniae | ? | - |
? | |
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)hex-4-ynoic acid + ATP | - |
Streptococcus pneumoniae | ? | - |
? | |
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)hex-5-enoic acid + ATP | - |
Streptococcus pneumoniae | ? | - |
? | |
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)pent-4-enoic acid + ATP | - |
Streptococcus pneumoniae | ? | - |
? | |
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)pent-4-ynoic acid + ATP | - |
Streptococcus pneumoniae | ? | - |
? | |
diphosphomevalonate + ATP | - |
Streptococcus pneumoniae | isopentenyl diphosphate + ADP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
diphosphomevalonate decarboxylase | - |
Streptococcus pneumoniae |
DPM-DC | - |
Streptococcus pneumoniae |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.018 | - |
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)-4-methylpentanoic acid | - |
Streptococcus pneumoniae | |
0.024 | - |
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)-5-methylhexanoic acid | - |
Streptococcus pneumoniae | |
0.21 | - |
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)hex-4-ynoic acid | - |
Streptococcus pneumoniae | |
0.27 | - |
(3R)-3-cyclopropyl-3-hydroxy-5-[[hydroxy(phosphonooxy)phosphoryl]oxy]pentanoic acid | - |
Streptococcus pneumoniae | |
0.39 | - |
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)hex-5-enoic acid | - |
Streptococcus pneumoniae | |
1.3 | - |
(3R)-3-ethyl-3-hydroxy-5-[[hydroxy(phosphonooxy)phosphoryl]oxy]pentanoic acid | - |
Streptococcus pneumoniae | |
1.3 | - |
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)pent-4-ynoic acid | - |
Streptococcus pneumoniae | |
3.2 | - |
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)pent-4-enoic acid | - |
Streptococcus pneumoniae | |
5.6 | - |
diphosphomevalonate | - |
Streptococcus pneumoniae |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.54 | - |
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)-4-methylpent-4-enoic acid | - |
Streptococcus pneumoniae | |
0.8 | - |
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)-5-methylhexanoic acid | - |
Streptococcus pneumoniae | |
1 | - |
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)-4-methylpentanoic acid | - |
Streptococcus pneumoniae | |
12 | - |
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)heptanoic acid | - |
Streptococcus pneumoniae | |
33 | - |
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)hex-4-ynoic acid | - |
Streptococcus pneumoniae | |
139 | - |
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)hex-5-enoic acid | - |
Streptococcus pneumoniae | |
270 | - |
(3R)-3-cyclopropyl-3-hydroxy-5-[[hydroxy(phosphonooxy)phosphoryl]oxy]pentanoic acid | - |
Streptococcus pneumoniae | |
448 | - |
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)pent-4-ynoic acid | - |
Streptococcus pneumoniae | |
866 | - |
(3R)-3-ethyl-3-hydroxy-5-[[hydroxy(phosphonooxy)phosphoryl]oxy]pentanoic acid | - |
Streptococcus pneumoniae | |
1882 | - |
(3R)-3-hydroxy-3-(2-[[hydroxy(phosphonooxy)phosphoryl]oxy]ethyl)pent-4-enoic acid | - |
Streptococcus pneumoniae | |
4666 | - |
diphosphomevalonate | - |
Streptococcus pneumoniae |