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Literature summary for 4.1.1.33 extracted from

  • Jabalquinto, A.M.; Cardemil, E.
    Kinetic effect of ATP, divalent metal ions and pH on chicken liver mevalonate 5-diphosphate decarboxylase (1987), Biochim. Biophys. Acta, 916, 172-178.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Cd2+
-
Gallus gallus
Mn2+
-
Gallus gallus
Zn2+
-
Gallus gallus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.029
-
ATP ATP in form of MnATP2- Gallus gallus
0.048
-
ATP ATP in form of CdATP2- Gallus gallus
0.202
-
ATP ATP in form of MgATP2- Gallus gallus
0.888
-
ATP ATP in form of ZnATP2- Gallus gallus

Metals/Ions

Metals/Ions Comment Organism Structure
Cd2+ MgCd2, activates at 37% of the activity of Mn2+ Gallus gallus
Mg2+ MgATP2-, activates at 14% of the activity with Mn2+ Gallus gallus
Mn2+ MnATP2-, best activator Gallus gallus

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (R)-5-diphosphomevalonate
-
Gallus gallus ADP + phosphate + isopentenyl diphosphate + CO2
-
?
ATP + 5-diphosphomevalonate
-
Gallus gallus ADP + phosphate + isopentenyl diphosphate + CO2
-
?

Cofactor

Cofactor Comment Organism Structure
ATP activates Gallus gallus