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Literature summary for 4.1.1.32 extracted from

  • Stark, R.; Guebre-Egziabher, F.; Zhao, X.; Feriod, C.; Dong, J.; Alves, T.C.; Ioja, S.; Pongratz, R.L.; Bhanot, S.; Roden, M.; Cline, G.W.; Shulman, G.I.; Kibbey, R.G.
    A role for mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) in the regulation of hepatic gluconeogenesis (2014), J. Biol. Chem., 289, 7257-7263.
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + oxaloacetate Rattus norvegicus
-
 GDP + phosphoenolpyruvate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + oxaloacetate
-
 Rattus norvegicus GDP + phosphoenolpyruvate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
PEPCK-M
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
GTP
-
 Rattus norvegicus

General Information

General Information Comment Organism
malfunction enzyme loss impairs gluconeogenesis from lactate, lowers plasma glucose, insulin, and triglycerides, reduces hepatic glycogen, and increases glycerol turnover Rattus norvegicus
metabolism approximately a third of gluconeogenesis comes from the enzyme Rattus norvegicus