Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.1.1.32 extracted from

  • Stark, R.; Pasquel, F.; Turcu, A.; Pongratz, R.L.; Roden, M.; Cline, G.W.; Shulman, G.I.; Kibbey, R.G.
    Phosphoenolpyruvate cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretion (2009), J. Biol. Chem., 284, 26578-26590.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.1.32

Inhibitors

Inhibitors Comment Organism Structure
Mg2+ Mg2+ reduces mitochondrial PEPCK activity Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-
mitochondrion
-
 Rattus norvegicus 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ Mn2+ is the preferred divalent of mitochondrial PEPCK Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + oxaloacetate Rattus norvegicus
-
 GDP + phosphoenolpyruvate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
 Rattus norvegicus
-
INS-1 832/13 cell
-
 Rattus norvegicus
-
pancreatic beta cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dGTP + oxaloacetate
-
 Rattus norvegicus dGDP + phosphoenolpyruvate + CO2
-
 ?
GTP + oxaloacetate
-
 Rattus norvegicus GDP + phosphoenolpyruvate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
PEPCK
-
 Rattus norvegicus
phosphoenolpyruvate carboxykinase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
GTP
-
 Rattus norvegicus