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Literature summary for 4.1.1.32 extracted from

  • Ash, D.E.; Emig, F.A.; Chowdhury, S.A.; Satoh, Y.; Schramm, V.L.
    Mammalian and avian liver phosphoenolpyruvate carboxykinase. Alternate substrates and inhibition by analogues of oxaloacetate (1990), J. Biol. Chem., 265, 7377-7384.
    View publication on PubMed
Search for more literature for 4.1.1.32

Inhibitors

Inhibitors Comment Organism Structure
beta-sulfopyruvate
-
 Gallus gallus
oxalate
-
 Gallus gallus
oxalate
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information Km-values for glycolate, thioglycolate and DL-beta-chlorolactate in phosphorylation reaction Gallus gallus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Gallus gallus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + oxaloacetate Gallus gallus first commited step of gluconeogenesis ?
-
 ?
GTP + oxaloacetate Rattus norvegicus first commited step of gluconeogenesis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-
Rattus norvegicus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2 the enzyme decarboxylates oxaloacetate to form the enolate of pyruvate which is then phosphorylated by MgGTP2- on the enzyme Gallus gallus
a
GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2 the enzyme decarboxylates oxaloacetate to form the enolate of pyruvate which is then phosphorylated by MgGTP2- on the enzyme Rattus norvegicus
a

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Gallus gallus
-
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + oxaloacetate
-
 Gallus gallus GDP + phosphoenolpyruvate + CO2
-
 ?
GTP + oxaloacetate
-
 Rattus norvegicus GDP + phosphoenolpyruvate + CO2
-
 ?
GTP + oxaloacetate first commited step of gluconeogenesis Gallus gallus ?
-
 ?
GTP + oxaloacetate first commited step of gluconeogenesis Rattus norvegicus ?
-
 ?
additional information catalyzes bicarbonate-dependent phosphorylation of hydroxylamine Gallus gallus ?
-
 ?
additional information catalyzes bicarbonate-dependent phosphorylation of hydroxylamine Rattus norvegicus ?
-
 ?
additional information enzyme catalyzes the phosphorylation of glycolate, thioglycolate, and DL-beta-chloroacetate Gallus gallus ?
-
 ?
additional information enzyme catalyzes the phosphorylation of glycolate, thioglycolate, and DL-beta-chloroacetate Rattus norvegicus ?
-
 ?