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Literature summary for 4.1.1.32 extracted from
- Phosphoenolpyruvate carboxykinase ferroactivator. Purification and some properties (1977), J. Biol. Chem., 252, 1431-1440.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Ferroactivator | ferroactivator + Fe2+, stimulates both directions of the reaction | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-oxoglutarate | - |
Rattus norvegicus |  |
| quinolinic acid | strongly inhibits the enzyme activated by ferroactivator and Fe2+, no inhibition of Mn2+-activated enzyme | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe2+ | Fe2+ alone does not stimulate, Fe2+ + ferroactivator, stimulate in both directions of the reaction | Rattus norvegicus | |
| Mn2+ | activates | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + oxaloacetate | - |
Rattus norvegicus | GDP + phosphoenolpyruvate + CO2 | - |
? | |
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