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Literature summary for 4.1.1.28 extracted from

  • Chalatsa, I.; Fragoulis, E.G.; Vassilacopoulou, D.
    Release of membrane-associated L-dopa decarboxylase from human cells (2011), Neurochem. Res., 36, 1426-1434.
    View publication on PubMed
Search for more literature for 4.1.1.28

Inhibitors

Inhibitors Comment Organism Structure
additional information increasing concentrations of the serine protease inhibitor aprotinin have a minimal inhibitory effect on enzyme solubilization while leupeptin inhibits release of membrane-bound enzyme Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information increasing concentrations of Zn2+ result in a raise in the solubilization of the membrane-associated enzyme, while the presence of increasing concentrations of Ca2+ and Mg2+ inhibits enzyme release from the MF sample Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55000
-
 x * 55000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-
SH-SY5Y cell
-
 Homo sapiens
-
U-87MG cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.01037
-
 solubilized enzyme, at pH 5.0 and 37°C, using L-Dopa as substrate Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Dopa
-
 Homo sapiens dopamine + CO2
-
 ?

Subunits

Subunits Comment Organism
? x * 55000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
DDC
-
 Homo sapiens
L-DOPA decarboxylase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate dependent on Homo sapiens