Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.1.1.28 extracted from

  • Chalatsa, I.; Nikolouzou, E.; Fragoulis, E.G.; Vassilacopoulou, D.
    L-Dopa decarboxylase expression profile in human cancer cells (2011), Mol. Biol. Rep., 38, 1005-1011.
    View publication on PubMed
Search for more literature for 4.1.1.28

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
 x * 50000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-Dopa Homo sapiens
-
 dopamine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocytoma cell
-
 Homo sapiens
-
cervical adenocarcinoma cell
-
 Homo sapiens
-
glioblastoma cell
-
 Homo sapiens
-
HeLa cell expression of neural-type and non-neural DDC isoforms, although HeLa cells express full length and the alternative Alt-DDC isoforms, they do not possess enzymatic activity towards the decarboxylation of L-Dopa Homo sapiens
-
J-82 cell expression of neural-type and non-neural DDC isoform Homo sapiens
-
neuroblastoma cell
-
 Homo sapiens
-
SH-SY5Y cell expression of neural-type DDC isoform Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00003
-
 enzyme from HTB-14 cells, at 37°C, pH not specified in the publication Homo sapiens
0.00006
-
 enzyme from HeLa cells, at 37°C, pH not specified in the publication Homo sapiens
10.03
-
 enzyme from SH-SY5Y cells, at 37°C, pH not specified in the publication Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Dopa
-
 Homo sapiens dopamine + CO2
-
 ?

Subunits

Subunits Comment Organism
? x * 50000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
AADC
-
 Homo sapiens
Alt-DDC alternative DDC protein isoform Homo sapiens
DDC
-
 Homo sapiens
L-DOPA decarboxylase
-
 Homo sapiens
neural-type DDC isoform Homo sapiens
non-neural DDC isoform Homo sapiens

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens DDC mRNA is transcribed in two different forms, neural and non-neural, due to alternative promoter usage and alternative splicing within the 5'-untranslated region additional information