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Literature summary for 4.1.1.28 extracted from

  • Allen, G.F.; Neergheen, V.; Oppenheim, M.; Fitzgerald, J.C.; Footitt, E.; Hyland, K.; Clayton, P.T.; Land, J.M.; Heales, S.J.
    Pyridoxal 5’-phosphate deficiency causes a loss of aromatic L-amino acid decarboxylase in patients and human neuroblastoma cells, implications for aromatic L-amino acid decarboxylase and vitamin B(6) deficiency states (2010), J. Neurochem., 114, 87-96.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
additional information pyridoxal 5'-phosphate deficiency reduces AADC activity Homo sapiens

General Stability

General Stability Organism
neither pyridoxal 5Â’-phosphate deficiency nor the addition of 4-deoxypyridoxine affected aromatic L-amino acid decarboxylase stability over 8 h with protein synthesis inhibited. Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.047
-
 L-5-hydroxytryptophan in the presence of 0.07 mM pyridoxal 5'-phosphate, in 167 mM sodium phosphate pH 8.0, at 37°C Homo sapiens
0.053
-
 L-5-hydroxytryptophan in the absence of pyridoxal 5'-phosphate Homo sapiens
0.307
-
 L-Dopa in the absence of pyridoxal 5'-phosphate, in 500 mM sodium phosphate pH 7.0, at 37°C Homo sapiens
0.333
-
 L-Dopa in the presence of 0.07 mM pyridoxal 5'-phosphate, in 500 mM sodium phosphate pH 7.0, at 37°C Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
 AADC is detected with two bands at approximately 50000 Da, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
SH-SY5Y cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-5-hydroxytryptophan
-
 Homo sapiens serotonin + CO2
-
 ?
L-Dopa
-
 Homo sapiens dopamine + CO2
-
 ?

Synonyms

Synonyms Comment Organism
AADC
-
 Homo sapiens
DOPA decarboxylase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate essential cofactor, pyridoxal 5'-phosphate deficiency causes a loss of aromatic L-amino acid decarboxylase Homo sapiens

Expression

Organism Comment Expression
Homo sapiens 4-deoxypyridoxine reduces aromatic L-amino acid decarboxylase mRNA levels down
Homo sapiens pyridoxal 5'-phosphate-deficient human SH-SY5Y neuroblastoma cells exhibit reduced levels of aromatic L-amino acid decarboxylase activity and protein but with no alteration in expression additional information