Application | Comment | Organism |
---|---|---|
drug development | Parkinson disease, gene therapy, initiation of a phase I safety trial | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
in a primate model of Parkinson disease, intrastriatal infusion of an adeno-associated viral vector containing the AADC gene results in robust gene expression | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-3,4-Dihydroxyphenylalanine | Homo sapiens | L-dopa | Dopamine + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuron | striatal neurons | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
after gene transfer in nondegenerating striatal neurons in patients, transgene expression of AADC can be monitored in the putamen | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-3,4-Dihydroxyphenylalanine | L-dopa | Homo sapiens | Dopamine + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Aromatic L-amino acid decarboxylase | - |
Homo sapiens |