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Literature summary for 4.1.1.28 extracted from
- Aromatic L-amino acid decarboxylase enzyme activity in deficient patients and heterozygotes (2007), Mol. Genet. Metab., 90, 363-369.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3,4-dihydroxyphenylalanine | inhibitory effect of 3,4-dihydroxyphenylalanine on the conversion of 5-hydroxy-L-tryptophan | Homo sapiens |  |
| 5-hydroxy indole acetic acid | the conversion of 5-hydroxy-L-tryptophan is 20% inhibited by 0.33 mM 5-hydroxy indole acetic acid | Homo sapiens | |
| 5-hydroxy-L-tryptophan | strong inhibitory effect of 5-hydroxy-L-tryptophan on the conversion of 3,4-dihydroxyphenylalanine | Homo sapiens | |
| carbidopa | strongly inhibited by increasing concentrations of carbidopa, at a concentration of 0.4 mM carbidopa the conversion of 3,4-dihydroxyphenylalanine is completely inhibited, at a concentration of 0.25 mM the conversion of 5-hydroxy-L-tryptophan is completely inhibited | Homo sapiens | |
| dopamine | the conversion of 5-hydroxy-L-tryptophan is strongly inhibited by dopamine | Homo sapiens | |
| additional information | not inhibited by 3-methoxy-tyrosine, homovanillic acid, or 5-hydroxy-tryptamine | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.49 | - |
5-hydroxy-L-tryptophan | in 167 mM phosphate buffer, pH 7.0, containing 39 mM dithiotreitol and 0.167 mM NaEDTA, for 2 h at 37°C | Homo sapiens | |
| 0.62 | - |
3,4-dihydroxyphenylalanine | in 167 mM phosphate buffer, pH 7.0, containing 39 mM dithiotreitol and 0.167 mM NaEDTA, for 2 h at 37°C | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3,4-Dihydroxyphenylalanine | - |
Homo sapiens | Dopamine + CO2 | - |
? | |
| 5-hydroxy-L-tryptophan | - |
Homo sapiens | serotonin + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AADC | - |
Homo sapiens |
| Aromatic L-amino acid decarboxylase | - |
Homo sapiens |
| DOPA decarboxylase | - |
Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
- |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.33 | - |
inhibits the conversion of 5-hydroxy-L-tryptophan | Homo sapiens | dopamine | |
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Release 2023.1 (January 2023)
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