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Literature summary for 4.1.1.28 extracted from

  • Bertoldi, M.; Borri Voltattorni, C.
    Reaction of dopa decarboxylase with L-aromatic amino acids under aerobic and anaerobic conditions (2000), Biochem. J., 352, 533-538.
No PubMed abstract available

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.035
-
L-Dopa pH 7.5, 25°C, anaerobiosis Sus scrofa
0.038
-
L-5-hydroxytryptophan pH 7.5, 25°C, anaerobiosis Sus scrofa
0.0703
-
L-Dopa pH 7.5, 25°C, aerobiosis Sus scrofa
0.155
-
L-5-hydroxytryptophan pH 7.5, 25°C, aerobiosis Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan Sus scrofa
-
tryptamine + CO2
-
?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
pig
-

Oxidation Stability

Oxidation Stability Organism
reaction specificity with D-aromatic amino acids does not change in presence or absence of O2, the reaction with L-aromatic amino acids seems to be affected by O2 Sus scrofa

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-5-hydroxytryptophan
-
Sus scrofa 5-hydroxytryptamine + CO2
-
?
L-Dopa
-
Sus scrofa dopamine + CO2
-
?
L-tryptophan
-
Sus scrofa tryptamine + CO2
-
?

Subunits

Subunits Comment Organism
homodimer
-
Sus scrofa

Synonyms

Synonyms Comment Organism
DDC
-
Sus scrofa
DOPA decarboxylase
-
Sus scrofa

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.99
-
L-5-hydroxytryptophan pH 7.5, 25°C, anaerobiosis Sus scrofa
1.99
-
L-5-hydroxytryptophan pH 7.5, 25°C, aerobiosis Sus scrofa
2.57
-
L-Dopa pH 7.5, 25°C, anaerobiosis Sus scrofa
2.94
-
L-5-hydroxytryptophan pH 7.5, 25°C, aerobiosis Sus scrofa
3 6 L-Dopa pH 7.5, 25°C, anaerobiosis Sus scrofa
3.13
-
L-Dopa pH 7.5, 25°C, aerobiosis Sus scrofa
4.26
-
L-Dopa pH 7.5, 25°C, aerobiosis Sus scrofa
6.08
-
L-5-hydroxytryptophan pH 7.5, 25°C, anaerobiosis Sus scrofa

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Sus scrofa