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Literature summary for 4.1.1.28 extracted from
- Aromatic L-amino acid decarboxylase: biological characterization and functional role (1995), Gen. Pharmacol., 26, 681-696.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Cavia porcellus | |
| additional information | - |
additional information | - |
Homo sapiens | |
| additional information | - |
additional information | - |
Rattus norvegicus | |
| additional information | - |
additional information | - |
Sus scrofa | |
| additional information | - |
additional information | - |
Bos taurus | |
| additional information | - |
additional information | - |
Xenopus laevis | |
| 0.4 | - |
3,4-dihydroxyphenylalanine | - |
Cavia porcellus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Cavia porcellus | the enzyme is responsible for the decarboxylation step in both the catecholamine and the indolamine synthetic pathways. The enzyme is regulated by a short term mechanism that may involve activation of adenyl cyclase or protein kinase C | ? | - |
? | |
| additional information | Homo sapiens | the enzyme is responsible for the decarboxylation step in both the catecholamine and the indolamine synthetic pathways. The enzyme is regulated by a short term mechanism that may involve activation of adenyl cyclase or protein kinase C | ? | - |
? | |
| additional information | Rattus norvegicus | the enzyme is responsible for the decarboxylation step in both the catecholamine and the indolamine synthetic pathways. The enzyme is regulated by a short term mechanism that may involve activation of adenyl cyclase or protein kinase C | ? | - |
? | |
| additional information | Sus scrofa | the enzyme is responsible for the decarboxylation step in both the catecholamine and the indolamine synthetic pathways. The enzyme is regulated by a short term mechanism that may involve activation of adenyl cyclase or protein kinase C | ? | - |
? | |
| additional information | Bos taurus | the enzyme is responsible for the decarboxylation step in both the catecholamine and the indolamine synthetic pathways. The enzyme is regulated by a short term mechanism that may involve activation of adenyl cyclase or protein kinase C | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Cavia porcellus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Sus scrofa | - |
- |
- |
| Xenopus laevis | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | - |
Rattus norvegicus | - |
| adrenal gland | adrenal medulla | Bos taurus | - |
| brain | - |
Rattus norvegicus | - |
| brain | - |
Sus scrofa | - |
| brain | brain stem | Homo sapiens | - |
| brain | brain stem | Bos taurus | - |
| corpus striatum | - |
Rattus norvegicus | - |
| corpus striatum | - |
Bos taurus | - |
| kidney | - |
Cavia porcellus | - |
| kidney | - |
Homo sapiens | - |
| kidney | - |
Sus scrofa | - |
| liver | - |
Rattus norvegicus | - |
| oocyte | - |
Xenopus laevis | - |
| PC-12 cell | - |
Rattus norvegicus | - |
| pineal gland | - |
Rattus norvegicus | - |
| pineal gland | - |
Bos taurus | - |
| retina | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3,4-Dihydroxyphenylalanine | - |
Cavia porcellus | 3-Hydroxytyramine + CO2 | - |
? | |
| 3,4-Dihydroxyphenylalanine | - |
Homo sapiens | 3-Hydroxytyramine + CO2 | - |
? | |
| 3,4-Dihydroxyphenylalanine | - |
Rattus norvegicus | 3-Hydroxytyramine + CO2 | - |
? | |
| 3,4-Dihydroxyphenylalanine | - |
Sus scrofa | 3-Hydroxytyramine + CO2 | - |
? | |
| 3,4-Dihydroxyphenylalanine | - |
Bos taurus | 3-Hydroxytyramine + CO2 | - |
? | |
| additional information | the enzyme is responsible for the decarboxylation step in both the catecholamine and the indolamine synthetic pathways. The enzyme is regulated by a short term mechanism that may involve activation of adenyl cyclase or protein kinase C | Cavia porcellus | ? | - |
? | |
| additional information | the enzyme is responsible for the decarboxylation step in both the catecholamine and the indolamine synthetic pathways. The enzyme is regulated by a short term mechanism that may involve activation of adenyl cyclase or protein kinase C | Homo sapiens | ? | - |
? | |
| additional information | the enzyme is responsible for the decarboxylation step in both the catecholamine and the indolamine synthetic pathways. The enzyme is regulated by a short term mechanism that may involve activation of adenyl cyclase or protein kinase C | Rattus norvegicus | ? | - |
? | |
| additional information | the enzyme is responsible for the decarboxylation step in both the catecholamine and the indolamine synthetic pathways. The enzyme is regulated by a short term mechanism that may involve activation of adenyl cyclase or protein kinase C | Sus scrofa | ? | - |
? | |
| additional information | the enzyme is responsible for the decarboxylation step in both the catecholamine and the indolamine synthetic pathways. The enzyme is regulated by a short term mechanism that may involve activation of adenyl cyclase or protein kinase C | Bos taurus | ? | - |
? | |
| Tyr | - |
Cavia porcellus | ? | - |
? | |
| Tyr | - |
Sus scrofa | ? | - |
? | |
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