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Literature summary for 4.1.1.28 extracted from

  • Nishigaki, I.; Ichinose, H.; Tamai, K.; Nagatsu, T.
    Purification of aromatic L-amino acid decarboxylase from bovine brain with a monoclonal antibody (1988), Biochem. J., 252, 331-335.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
pyridoxal 5'-phosphate inhibition at high concentrations, stimulation at lower concentration Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.14
-
3,4-dihydroxyphenylalanine brain enzyme Bos taurus
0.16
-
3,4-dihydroxyphenylalanine
-
Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
2 * 50000, SDS-PAGE Bos taurus
100000
-
gel filtration Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
affinity chromatography using monoclonal antibody Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland adrenal medulla Bos taurus
-
brain
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.043
-
brain enzyme Bos taurus
0.19
-
adrenal medulla enzyme Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,4-Dihydroxyphenylalanine
-
Bos taurus 3-Hydroxytyramine + CO2
-
?

Subunits

Subunits Comment Organism
dimer 2 * 50000, SDS-PAGE Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
-
Bos taurus

pH Range

pH Minimum pH Maximum Comment Organism
5 8.5 pH 5.0: about 45% of maximal activity, pH 8.5: about 45% of maximal activity, adrenal medulla enzyme Bos taurus
5.5 8.5 pH 5.5: about 55% of maximal activity, pH 8.5: about 35% of maximal activity, brain enzyme Bos taurus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate stimulates, high concentrations inhibit Bos taurus