Literature summary for 4.1.1.23 extracted from

Meza-Avina, M.E.; Wei, L.; Buhendwa, M.G.; Poduch, E.; Bello, A.M.; Pai, E.F.; Kotra, L.P.
Inhibition of orotidine 5-monophosphate decarboxylase and its therapeutic potential (2008), Mini Rev. Med. Chem., 8, 239-247.

Inhibitors

Inhibitors	Comment	Organism
6-aminouridine 5'-monophosphate	-	Bacillus subtilis
6-aminouridine 5'-monophosphate	-	Escherichia coli
6-aminouridine 5'-monophosphate	-	Homo sapiens
6-aminouridine 5'-monophosphate	-	Methanococcus thermoautotrophicum
6-aminouridine 5'-monophosphate	-	Plasmodium falciparum
6-aminouridine 5'-monophosphate	-	Plasmodium vivax
6-aminouridine 5'-monophosphate	-	Saccharomyces cerevisiae
6-azauridine 5'-monophosphate	-	Bacillus subtilis
6-azauridine 5'-monophosphate	-	Escherichia coli
6-azauridine 5'-monophosphate	-	Homo sapiens
6-azauridine 5'-monophosphate	-	Methanococcus thermoautotrophicum
6-azauridine 5'-monophosphate	-	Plasmodium falciparum
6-azauridine 5'-monophosphate	-	Plasmodium vivax
6-azauridine 5'-monophosphate	-	Saccharomyces cerevisiae
6-cyanouridine 5'-monophosphate	-	Bacillus subtilis
6-cyanouridine 5'-monophosphate	-	Escherichia coli
6-cyanouridine 5'-monophosphate	-	Homo sapiens
6-cyanouridine 5'-monophosphate	-	Methanococcus thermoautotrophicum
6-cyanouridine 5'-monophosphate	-	Plasmodium falciparum
6-cyanouridine 5'-monophosphate	-	Plasmodium vivax
6-cyanouridine 5'-monophosphate	-	Saccharomyces cerevisiae
6-iodouridine 5'-monophosphate	-	Bacillus subtilis
6-iodouridine 5'-monophosphate	-	Escherichia coli
6-iodouridine 5'-monophosphate	-	Homo sapiens
6-iodouridine 5'-monophosphate	-	Methanococcus thermoautotrophicum
6-iodouridine 5'-monophosphate	-	Plasmodium falciparum
6-iodouridine 5'-monophosphate	-	Plasmodium vivax
6-iodouridine 5'-monophosphate	-	Saccharomyces cerevisiae
6-thiocarboxamidouridine 5'-monophosphate	-	Bacillus subtilis
6-thiocarboxamidouridine 5'-monophosphate	-	Escherichia coli
6-thiocarboxamidouridine 5'-monophosphate	-	Homo sapiens
6-thiocarboxamidouridine 5'-monophosphate	-	Methanococcus thermoautotrophicum
6-thiocarboxamidouridine 5'-monophosphate	-	Plasmodium falciparum
6-thiocarboxamidouridine 5'-monophosphate	-	Plasmodium vivax
6-thiocarboxamidouridine 5'-monophosphate	-	Saccharomyces cerevisiae
barbituric acid ribonucleoside 5'-monophosphate	-	Bacillus subtilis
barbituric acid ribonucleoside 5'-monophosphate	-	Escherichia coli
barbituric acid ribonucleoside 5'-monophosphate	-	Homo sapiens
barbituric acid ribonucleoside 5'-monophosphate	-	Methanococcus thermoautotrophicum
barbituric acid ribonucleoside 5'-monophosphate	-	Plasmodium falciparum
barbituric acid ribonucleoside 5'-monophosphate	-	Plasmodium vivax
barbituric acid ribonucleoside 5'-monophosphate	-	Saccharomyces cerevisiae
pyrazofurin 5'-monophosphate	-	Bacillus subtilis
pyrazofurin 5'-monophosphate	-	Escherichia coli
pyrazofurin 5'-monophosphate	-	Homo sapiens
pyrazofurin 5'-monophosphate	-	Methanococcus thermoautotrophicum
pyrazofurin 5'-monophosphate	-	Plasmodium falciparum
pyrazofurin 5'-monophosphate	-	Plasmodium vivax
pyrazofurin 5'-monophosphate	-	Saccharomyces cerevisiae
xanthosine 5'-monophosphate	-	Bacillus subtilis
xanthosine 5'-monophosphate	-	Escherichia coli
xanthosine 5'-monophosphate	-	Homo sapiens
xanthosine 5'-monophosphate	-	Methanococcus thermoautotrophicum
xanthosine 5'-monophosphate	-	Plasmodium falciparum
xanthosine 5'-monophosphate	-	Plasmodium vivax
xanthosine 5'-monophosphate	-	Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.
Orotidine 5'-phosphate	Bacillus subtilis	-	UMP + CO2	-	?
Orotidine 5'-phosphate	Escherichia coli	-	UMP + CO2	-	?
Orotidine 5'-phosphate	Homo sapiens	-	UMP + CO2	-	?
Orotidine 5'-phosphate	Saccharomyces cerevisiae	-	UMP + CO2	-	?
Orotidine 5'-phosphate	Plasmodium falciparum	-	UMP + CO2	-	?
Orotidine 5'-phosphate	Plasmodium vivax	-	UMP + CO2	-	?
Orotidine 5'-phosphate	Methanococcus thermoautotrophicum	-	UMP + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Bacillus subtilis	-	-	-
Escherichia coli	-	-	-
Homo sapiens	-	-	-
Methanococcus thermoautotrophicum	-	-	-
Plasmodium falciparum	-	-	-
Plasmodium vivax	-	-	-
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
Orotidine 5'-phosphate	-	Bacillus subtilis	UMP + CO2	-	?
Orotidine 5'-phosphate	-	Escherichia coli	UMP + CO2	-	?
Orotidine 5'-phosphate	-	Homo sapiens	UMP + CO2	-	?
Orotidine 5'-phosphate	-	Saccharomyces cerevisiae	UMP + CO2	-	?
Orotidine 5'-phosphate	-	Plasmodium falciparum	UMP + CO2	-	?
Orotidine 5'-phosphate	-	Plasmodium vivax	UMP + CO2	-	?
Orotidine 5'-phosphate	-	Methanococcus thermoautotrophicum	UMP + CO2	-	?

Subunits

Subunits	Comment	Organism
dimer	-	Bacillus subtilis
dimer	-	Escherichia coli
dimer	-	Homo sapiens
dimer	-	Saccharomyces cerevisiae
dimer	-	Plasmodium falciparum
dimer	-	Plasmodium vivax
dimer	-	Methanococcus thermoautotrophicum

Synonyms

Synonyms	Comment	Organism
ODCase	-	Bacillus subtilis
ODCase	-	Escherichia coli
ODCase	-	Homo sapiens
ODCase	-	Saccharomyces cerevisiae
ODCase	-	Plasmodium falciparum
ODCase	-	Plasmodium vivax
ODCase	-	Methanococcus thermoautotrophicum
Orotidine 5'-monophosphate decarboxylase	-	Bacillus subtilis
Orotidine 5'-monophosphate decarboxylase	-	Escherichia coli
Orotidine 5'-monophosphate decarboxylase	-	Homo sapiens
Orotidine 5'-monophosphate decarboxylase	-	Saccharomyces cerevisiae
Orotidine 5'-monophosphate decarboxylase	-	Plasmodium falciparum
Orotidine 5'-monophosphate decarboxylase	-	Plasmodium vivax
Orotidine 5'-monophosphate decarboxylase	-	Methanococcus thermoautotrophicum