General Stability | Organism |
---|---|
1-ribosyloxipurinol 5'-phosphate prevents loss of activity during preincubation in absence of substrate, when the inhibitor concentration is high enough to inhibit the enzyme substantially | Saccharomyces cerevisiae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-Ribosyloxipurinol 5'-phosphate | most effective oxipurinol nucleotide inhibitor | Saccharomyces cerevisiae | |
3-Xanthosine 5'-phosphate | - |
Saccharomyces cerevisiae | |
7-Ribosyloxipurinol 5'-phosphate | - |
Saccharomyces cerevisiae | |
oxipurinol nucleotides | potent, competitive, bimodal. The inhibition of the enzyme by oxipurinol nucleotides is primarily responsible for the increased urinary excretion of orotic acid and orotidine in patients treated with allopurinol | Saccharomyces cerevisiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Orotidine 5'-phosphate | - |
Saccharomyces cerevisiae | UMP + CO2 | - |
? |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
half life: 26 min | Saccharomyces cerevisiae |
37 | - |
half-life: 10 min. Nucleotide inhibitors stabilize against inactivation at 37°C | Saccharomyces cerevisiae |