Literature summary for 4.1.1.22 extracted from

Nitta, Y.; Kikuzaki, H.; Azuma, T.; Ye, Y.; Sakaue, M.; Higuchi, Y.; Komori, H.; Ueno, H.
Inhibitory activity of Filipendula ulmaria constituents on recombinant human histidine decarboxylase (2013), Food Chem., 138, 1551-1556.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Histidine methyl ester	mixed-type inhibition	Homo sapiens
rugosin A	compound isolated from Filipendula ulmaria, non-competitive	Homo sapiens
rugosin A methyl ester	compound isolated from Filipendula ulmaria, non-competitive	Homo sapiens
rugosin D	compound isolated from Filipendula ulmaria, non-competitive	Homo sapiens
tellimagrandin II	compound isolated from Filipendula ulmaria, non-competitive	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P19113	-	-

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00035	-	rugosin D	pH 6.8, 37°C	Homo sapiens
0.00041	-	rugosin A methyl ester	pH 6.8, 37°C	Homo sapiens
0.00046	-	Histidine methyl ester	pH 6.8, 37°C	Homo sapiens
0.00094	-	tellimagrandin II	pH 6.8, 37°C	Homo sapiens
0.001	-	rugosin A	pH 6.8, 37°C	Homo sapiens

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Release 2023.1 (January 2023)