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Literature summary for 4.1.1.22 extracted from

  • Funayama, H.; Huang, L.; Asada, Y.; Endo, Y.; Takada, H.
    Enhanced induction of a histamine-forming enzyme, histidine decarboxylase, in mice primed with NOD1 or NOD2 ligand in response to various Toll-like receptor agonists (2010), Innate Immun., 16, 265-272.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
liver
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Mus musculus
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lung
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Mus musculus
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spleen
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Mus musculus
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Synonyms

Synonyms Comment Organism
HDC
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Mus musculus

Expression

Organism Comment Expression
Mus musculus intravenous injection of Toll-like receptor (TLR)-4-agonistic synthetic lipid A definitely induces HDC activity in the liver, spleen, and lungs, especially the lungs, in mice (maximum activity is induced after about 3 h). The TLR2/6 agonistic synthetic diacyl-type lipopeptide FSL-1 and TLR3-agonistic poly I:C are also effective in inducing HDC, while the NOD2-agonistic synthetic muramyldipeptide (5 mg/kg) and NOD1-agonistic synthetic FK156 (D-lactyl-L-Ala-gamma-D-Glu-meso-DAP-Gly, 0.01-0.1 mg/kg), and FK565 (heptanoyl-g-D-Glu-meso-DAP-D-Ala, 0.5 mg/kg) exhibit only weak activities in this respect. Mice primed with intravenous injection of NOD1 or NOD2 agonists produce higher HDC activity following the 4-6 h later intravenous challenge with the above TLR agonists up