Literature summary for 4.1.1.22 extracted from

Fleming, J.V.; Wang, T.C.
The production of 53-55-kDa isoforms is not required for rat L-histidine decarboxylase dctivity (2003), J. Biol. Chem., 278, 686-694.

Search for more literature for 4.1.1.22

Activating Compound

Activating Compound	Comment	Organism	Structure
gastrin	increase of steady-state levels of 6 HDC isoforms	Rattus norvegicus

Cloned(Commentary)

Cloned (Comment)	Organism
expression in COS-7 cells	Rattus norvegicus
expression of cDNA in COS-7 cells	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-histidine	Rattus norvegicus	-	histamine + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	post-translational processing of 74000 Da HDC is required for activity, carboxyl-terminal processing generates an active 55000 Da isoform and additional isoforms with molecular weights higher than 55000 Da	Rattus norvegicus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-histidine	-	Rattus norvegicus	histamine + CO2	-	?

Subunits

Subunits	Comment	Organism
More	five HDC isoforms of 63000 Da, 54000 Da, 48000 Da, 40000 Da and 36000 Da, that derive from the 74000 Da full-length primary translation isoform	Rattus norvegicus

Synonyms

Synonyms	Comment	Organism
HDC	-	Rattus norvegicus

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Release 2023.1 (January 2023)