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Literature summary for 4.1.1.18 extracted from
- Lysine decarboxylase expression by Vibrio vulnificus is induced by SoxR in response to superoxide stress (2006), J. Bacteriol., 188, 8586-8592.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | the enzyme is upregulated by CadC in response to acid stress, and is also induced by SoxR in response to superoxide stress, SoxR binds directly to the promoter region of the cadBA operon, coding for a lysine-cadaverine antiporter, CadB, and the lysine decarboxylase CadA | Vibrio vulnificus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene cadA, encoded in the cadBA operon, also coding for a lysine-cadaverine antiporter, CadB, expression of cadA in Escherichia coli strain S17-1 and S17-1lambdapir, transcription of cadBA in a pH-dependent manner, overview | Vibrio vulnificus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | a lack of cadaverine caused by mutation in cadA results in low tolerance to oxidative stress compared to the wild type, cadaverine, which neutralizes the external medium, also appears to scavenge superoxide radicals, since increasing cellular cadaverine by elevating the gene dosage of cadBA significantly diminished the induction of Mn-containing superoxide dismutase under methyl viologen-induced oxidative stress, overview | Vibrio vulnificus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-lysine | Vibrio vulnificus | - |
cadaverine + CO2 | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Vibrio vulnificus | - |
gene cadA | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
pH-dependent enzyme activities, overview | Vibrio vulnificus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-lysine | - |
Vibrio vulnificus | cadaverine + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CadA | - |
Vibrio vulnificus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Vibrio vulnificus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5 | 7.5 | assay at, transcription of cadBA in a pH-dependent manner, overview | Vibrio vulnificus |
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Release 2023.1 (January 2023)
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