Literature summary for 4.1.1.18 extracted from

Tanaka, Y.; Kimura, B.; Takahashi, H.; Watanabe, T.; Obata, H.; Kai, A.; Morozumi, S.; Fujii, T.
Lysine decarboxylase of Vibrio parahaemolyticus: kinetics of transcription and role in acid resistance (2007), J. Appl. Microbiol., 104, 1283-1293.

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	the enzyme is encoded in an acid-induced operon	Vibrio parahaemolyticus

Cloned(Commentary)

Cloned (Comment)	Organism
gene cadA from strain V02-64, DNA and amino acid sequence, and gene cluster and intergenic region determination and analysis, subcloning in Escherichia coli, quantitative analysis of lysine decarboxylase expression levels dependent on acid conditions at pH 4.0-7.5, primer extension analysis, the gene encoding the enzyme is located in an acid-induced operon, overview, cadA mRNA exhibited about 40fold greater expression at pH 5.0 than at pH 5.5, in cells exposed to pH 7.5, the cadA transcript shows the largest quantity under all conditions, the amount of cadA single transcript is nearly 100fold higher than the polycistronic cadBA transcript for each pH condition	Vibrio parahaemolyticus

Cloned (Comment)

Organism

gene cadA from strain V02-64, DNA and amino acid sequence, and gene cluster and intergenic region determination and analysis, subcloning in Escherichia coli, quantitative analysis of lysine decarboxylase expression levels dependent on acid conditions at pH 4.0-7.5, primer extension analysis, the gene encoding the enzyme is located in an acid-induced operon, overview, cadA mRNA exhibited about 40fold greater expression at pH 5.0 than at pH 5.5, in cells exposed to pH 7.5, the cadA transcript shows the largest quantity under all conditions, the amount of cadA single transcript is nearly 100fold higher than the polycistronic cadBA transcript for each pH condition

Vibrio parahaemolyticus

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of a cadA gene-inactivated strain from wild-type strain V02-64, serotype O3:K, by a plasmid integrated in its chromosome, single crossing over, acid resistance of the mutant strain at pH 4.0 in phosphate buffer is weaker than in the parental strain	Vibrio parahaemolyticus

Organism

Organism	UniProt	Comment	Textmining
Vibrio parahaemolyticus	Q87KT6	several acid adapted and nonadapted strains, gene cadA or VP2890	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	lysine decarboxylase-dependent acid-tolerance assays, overview	Vibrio parahaemolyticus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
additional information	-	survival of acid adapted and nonadpted strains at pH 5.5 and pH 7.5, 30°C, overview	Vibrio parahaemolyticus