Literature summary for 4.1.1.1 extracted from

Tylicki, A.; Ziolkowska, G.; Bolkun, A.; Siemieniuk, M.; Czerniecki, J.; Nowakiewicz, A.
Comparative study of the activity and kinetic properties of malate dehydrogenase and pyruvate decarboxylase from Candida albicans, Malassezia pachydermatis, and Saccharomyces cerevisiae (2008), Can. J. Microbiol., 54, 734-741.

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KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.8	-	pyruvate	-	Candida albicans
2.29	-	pyruvate	-	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Candida albicans	-	-	-
no activity in Malassezia pachydermatis	-	-	-
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
pyruvate	-	Saccharomyces cerevisiae	acetaldehyde + CO2	-	?
pyruvate	-	Candida albicans	acetaldehyde + CO2	-	?

Synonyms

Synonyms	Comment	Organism
PDC	-	Saccharomyces cerevisiae
PDC	-	Candida albicans

Cofactor

Cofactor	Comment	Organism	Structure
thiamine diphosphate	0.1 mM, required for activity	Saccharomyces cerevisiae
thiamine diphosphate	0.1 mM, required for activity	Candida albicans

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Release 2023.1 (January 2023)