Literature summary for 4.1.1.1 extracted from

Fredlund, E.; Beerlage, C.; Melin, P.; Schnuerer, J.; Passoth, V.
Oxygen and carbon source-regulated expression of PDC and ADH genes in the respiratory yeast Pichia anomala (2006), Yeast, 23, 1137-1149.

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	PDC1 is expressed during aerobic growth on glucose and is upregulated 4fold in response to oxygen limitation, PDC1 expression is lower in cells grown on ethanol and succinate than on glucose and is up regulated 2-4fold, respectively, after glucose addition	Wickerhamomyces anomalus

Cloned(Commentary)

Cloned (Comment)	Organism
gene pdc1, DNA and amino acid sequence determination and analysis, cloning of the flanking regions, expression analysis, enzyme expression is regulated by hypoxia and carbon source but posttranscriptional regulation may play a major role in regulating the metabolic flux, PDC1 is expressed during aerobic growth on glucose and is upregulated 4fold in response to oxygen limitation, PDC1 expression is lower in cells grown on ethanol and succinate than on glucose and is up regulated 2-4fold, respectively, after glucose addition	Wickerhamomyces anomalus

Cloned (Comment)

Organism

gene pdc1, DNA and amino acid sequence determination and analysis, cloning of the flanking regions, expression analysis, enzyme expression is regulated by hypoxia and carbon source but posttranscriptional regulation may play a major role in regulating the metabolic flux, PDC1 is expressed during aerobic growth on glucose and is upregulated 4fold in response to oxygen limitation, PDC1 expression is lower in cells grown on ethanol and succinate than on glucose and is up regulated 2-4fold, respectively, after glucose addition

Wickerhamomyces anomalus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Wickerhamomyces anomalus	5737	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Wickerhamomyces anomalus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
pyruvate	Wickerhamomyces anomalus	enzyme expression is regulated by hypoxia and carbon source but posttranscriptional regulation may play a major role in regulating the metabolic flux	acetaldehyde + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Wickerhamomyces anomalus	Q659I2	i.e. Candida pelliculosa or Hansenula anomala, diploid type strain NRRL-Y-366, haploid strain NRRL-Y-366-8, gene pdc1	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
pyruvate	-	Wickerhamomyces anomalus	acetaldehyde + CO2	-	?
pyruvate	enzyme expression is regulated by hypoxia and carbon source but posttranscriptional regulation may play a major role in regulating the metabolic flux	Wickerhamomyces anomalus	acetaldehyde + CO2	-	?

Synonyms

Synonyms	Comment	Organism
PDC1	-	Wickerhamomyces anomalus

Cofactor

Cofactor	Comment	Organism	Structure
thiamine diphosphate	-	Wickerhamomyces anomalus