Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.1.1.1 extracted from

  • Zhang, S.; Liu, M.; Yan, Y.; Zhang, Z.; Jordan, F.
    C2-alpha-lactylthiamin diphosphate is an intermediate on the pathway of thiamin diphosphate-dependent pyruvate decarboxylation. Evidence on enzymes and models (2004), J. Biol. Chem., 279, 54312-54318.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
E477Q/E91D retains catalytic activity Saccharomyces cerevisiae
E51D/E91D no residual catalytic activity Saccharomyces cerevisiae
E91D racemic C2-alpha-lactylthiamine diphosphate exposed to mutant enzyme is partitioned between reversion to pyruvate and decarboxylation Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Reaction

Reaction Comment Organism Reaction ID
a 2-oxo carboxylate = an aldehyde + CO2 enzyme forms covalent intermediate C2-alpha-lactylthiamine diphosphate. Rate of reaction is limited by release of thiamine diphosphate Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
thiamine diphosphate enzyme forms covalent intermediate C2-alpha-lactylthiamine diphosphate Saccharomyces cerevisiae