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Literature summary for 3.9.1.3 extracted from

  • Panda, S.; Srivastava, S.; Li, Z.; Vaeth, M.; Fuhs, S.R.; Hunter, T.; Skolnik, E.Y.
    Identification of PGAM5 as a mammalian protein histidine phosphatase that plays a central role to negatively regulate CD4(+) T cells (2016), Mol. Cell, 63, 457-469 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.9.1.3

Protein Variants

Protein Variants Comment Organism
H105A the mutant enzyme shows no dephosphorylation of nucleoside diphosphate kinase B Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mus musculus 5739
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[nucleoside diphosphate kinase B]-N-phospho-L-histidine + H2O Mus musculus the enzyme (PGAM5) specifically associates with and dephosphorylates the catalytic histidine (H118) on nucleoside diphosphate kinase B (NDPK-B). By dephosphorylating NDPK-B, the enzyme (PGAM5) negatively regulates CD4+ T cells by inhibiting NDPK-B mediated histidine phosphorylation and activation of the K+ channel KCa3.1, which is required for T cell receptor stimulated Ca2+ influx and cytokine production [nucleoside diphosphate kinase B]-L-histidine + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8BX10 cf. EC 3.1.3.16
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Purification (Commentary)

Purification (Comment) Organism
expression in Escherichia coli Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[nucleoside diphosphate kinase B]-N-phospho-L-histidine + H2O the enzyme (PGAM5) specifically associates with and dephosphorylates the catalytic histidine (H118) on nucleoside diphosphate kinase B (NDPK-B). By dephosphorylating NDPK-B, the enzyme (PGAM5) negatively regulates CD4+ T cells by inhibiting NDPK-B mediated histidine phosphorylation and activation of the K+ channel KCa3.1, which is required for T cell receptor stimulated Ca2+ influx and cytokine production Mus musculus [nucleoside diphosphate kinase B]-L-histidine + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PGAM5
-
 Mus musculus

General Information

General Information Comment Organism
malfunction Pgam5-/- T cells cause accelerated and more severe Graft versus host disease (GvHD) in mice Mus musculus
physiological function the enzyme plays a central role to negatively regulate CD4+ T cells. It specifically associates with and dephosphorylates the catalytic histidine (H118) on nucleoside diphosphate kinase B (NDPK-B). By dephosphorylating NDPK-B, the enzyme (PGAM5) negatively regulates CD4+ T cells by inhibiting NDPK-B mediated histidine phosphorylation and activation of the K+ channel KCa3.1, which is required for T cell receptor stimulated Ca2+ influx and cytokine production Mus musculus