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Literature summary for 3.9.1.3 extracted from

  • Schulte, J.E.; Goulian, M.
    The phosphohistidine phosphatase SixA targets a phosphotransferase system (2018), mBio, 9, e01666-18 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.9.1.3

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[Escherichia coli histidine kinase ArcB]-N-phospho-L-histidine + H2O Escherichia coli
-
 [Escherichia coli histidine kinase ArcB]-L-histidine + phosphate
-
 ?
[Escherichia coli histidine kinase ArcB]-N-phospho-L-histidine + H2O Escherichia coli K12
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 [Escherichia coli histidine kinase ArcB]-L-histidine + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli P76502
-
-
Escherichia coli K12 P76502
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[Escherichia coli histidine kinase ArcB]-N-phospho-L-histidine + H2O
-
 Escherichia coli [Escherichia coli histidine kinase ArcB]-L-histidine + phosphate
-
 ?
[Escherichia coli histidine kinase ArcB]-N-phospho-L-histidine + H2O
-
 Escherichia coli K12 [Escherichia coli histidine kinase ArcB]-L-histidine + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
SixA
-
 Escherichia coli

General Information

General Information Comment Organism
malfunction DELTAsixA cells have lower intracellular potassium levels than wild-type cells Escherichia coli
metabolism the enzyme targets a phosphotransferase system. A model is suggested in which SixA removes phosphoryl groups from the PTSNtr by acting on NPr. The PTSNtr is a widely conserved bacterial pathway that regulates diverse metabolic processes through the phosphorylation states of its protein components, EINtr, NPr, and EIIANtr, which receive phosphoryl groups on histidine residues Escherichia coli
physiological function the enzyme does not affects ArcB/ArcA signaling in vivo Escherichia coli