Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NRX4 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatic stellate cell | enzyme (PHP14) expression is upregulated in fibrotic liver and mainly in hepatic stellate cells | Homo sapiens | - |
liver | enzyme (PHP14) expression is upregulated in fibrotic liver and mainly in hepatic stellate cells | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
PHP14 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | PHP14 expression is upregulated in fibrotic liver and mainly in hepatic stellate cells. TGF-beta1 can induce PHP14 expression in hepatic stellate cells accompanied with the activation of hepatic stellate cells | up |
General Information | Comment | Organism |
---|---|---|
metabolism | PHP14 promotes hepatic stellate cell migration, especially, promotes 3D floating collagen matrices contraction but inhibits stress released matrices contraction. Mechanistically, the PI3Kgamma/AKT/Rac1 pathway is involved in migration regulated by PHP14. Moreover, PHP14 specifically mediates the TGF-beta1 signaling to PI3Kgamma/AKT pathway and regulates HSC migration, and thus participates in liver fibrosis | Homo sapiens |
physiological function | the enzyme (PHP14) regulates hepatic stellate cells migration in liver fibrosis via mediating TGF-beta1 signaling to PI3Kgamma/AKT/Rac1 pathway | Homo sapiens |