Literature summary for 3.9.1.3 extracted from

Xu, A.; Hao, J.; Zhang, Z.; Tian, T.; Jiang, S.; Hao, J.; Liu, C.; Huang, L.; Xiao, X.; He, D.
14-kDa phosphohistidine phosphatase and its role in human lung cancer cell migration and invasion (2010), Lung Cancer, 67, 48-56.

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Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
14000	-	x * 14000, SDS-PAGE	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
a [protein]-N-phospho-L-histidine + H2O	Homo sapiens	-	a [protein]-L-histidine + phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9NRX4	-	-

Purification (Commentary)

Purification (Comment)	Organism
Ni-NTA column chromatography	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
CL1-5 cell	-	Homo sapiens	-
H-1299 cell	-	Homo sapiens	-
lung cancer cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
a [protein]-N-phospho-L-histidine + H2O	-	Homo sapiens	a [protein]-L-histidine + phosphate	-	?

Subunits

Subunits	Comment	Organism
?	x * 14000, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
14-kDa phosphohistidine phosphatase	-	Homo sapiens
PHP14	-	Homo sapiens
PHPT1	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	enzyme knockdown in highly metastatic lung cancer CL1-5 cells inhibits migration and invasion in vitro, but does not alter cell proliferation rates, while enzyme overexpression in H1299 cells promotes migration and invasion in vitro, but again does not alter cell proliferation	Homo sapiens
physiological function	the enzyme is involved in cytoskeletal reorganization and therfore is functionally important in lung cancer cell migration and the invasion of lung cancer cells, mediated partly through modulation of actin cytoskeleton rearrangement	Homo sapiens

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Release 2023.1 (January 2023)