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Literature summary for 3.9.1.3 extracted from

  • Eissing, A.; Fischer, D.; Rauch, I.; Baumann, A.; Schebb, N.H.; Karst, U.; Rose, K.; Klumpp, S.; Krieglstein, J.
    Acetylcholine content and viability of cholinergic neurons are influenced by the activity of protein histidine phosphatase (2012), BMC Neurosci., 13, 31.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
H53A inactive Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[ATP-citrate lyase]-N-phospho-L-histidine + H2O Mus musculus
-
[ATP-citrate lyase]-L-histidine + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
SN-56 cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[ATP-citrate lyase]-N-phospho-L-histidine + H2O
-
Mus musculus [ATP-citrate lyase]-L-histidine + phosphate
-
?

Synonyms

Synonyms Comment Organism
PHP
-
Mus musculus
protein histidine phosphatase
-
Mus musculus

General Information

General Information Comment Organism
malfunction enzyme downregulation does not induce cell death, but significantly increases the acetylcholine content in SN-56 cells Mus musculus
metabolism the enzyme downregulates the activity of ATP-citrate lyase by dephosphorylation Mus musculus
physiological function enzyme overexpression reduces the acetylcholine level and induces cell death Mus musculus