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Literature summary for 3.9.1.3 extracted from
- Phosphohistidine and phospholysine phosphatase activities in the rat: potential protein-lysine and protein-histidine phosphatases? (1993), Biochem. J., 296, 293-296.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Calmodulin | 115% activity at 5 mM Ca2+ plus 0.01 mM calmodulin | Rattus norvegicus |  |
| iodoacetamide | 131% activity at 1 mM | Rattus norvegicus | |
| additional information | slightly increased activity in the presence of 5,5'-dithiobis-2-nitrobenzoic acid and GSH | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | 73% residual activity at 5 mM | Rattus norvegicus | |
| additional information | not inactivated by EDTA | Rattus norvegicus | |
| N-ethylmaleimide | 74% residual activity at 1 mM | Rattus norvegicus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | 130% activity at 5 mM | Rattus norvegicus | |
| Mg2+ | 260% activity at 5 mM | Rattus norvegicus | |
| Mn2+ | 122% activity at 5 mM | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| a [protein]-N-phospho-L-histidine + H2O | Rattus norvegicus | - |
a [protein]-L-histidine + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| DE-52 cellulose column chromatography | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| heart | - |
Rattus norvegicus | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
| lung | - |
Rattus norvegicus | - |
| skeletal muscle | - |
Rattus norvegicus | - |
| spleen | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| a [protein]-N-phospho-L-histidine + H2O | - |
Rattus norvegicus | a [protein]-L-histidine + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| phosphopolyhistidine phosphatase | - |
Rattus norvegicus |
| PHPT1 | - |
Rattus norvegicus |
| protein-histidine phosphatase | - |
Rattus norvegicus |
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