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Literature summary for 3.8.1.10 extracted from

  • Kurihara, T.
    A mechanistic analysis of enzymatic degradation of organohalogen compounds (2011), Biosci. Biotechnol. Biochem., 75, 189-198.
    View publication on PubMed
Search for more literature for 3.8.1.10

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(R)-2-chloropropionic acid + H2O Pseudomonas sp.
-
 (S)-2-hydroxypropionic acid + chloride
-
 ?
(R)-2-chloropropionic acid + H2O Pseudomonas sp. 113
-
 (S)-2-hydroxypropionic acid + chloride
-
 ?
(S)-2-chloropropionic acid + H2O Pseudomonas sp.
-
 (R)-2-hydroxypropionic acid + chloride
-
 ?
(S)-2-chloropropionic acid + H2O Pseudomonas sp. 113
-
 (R)-2-hydroxypropionic acid + chloride
-
 ?

Organism

Organism UniProt Comment Textmining
Pseudomonas sp.
-
-
-
Pseudomonas sp. 113
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-2-chloropropionic acid + H2O
-
 Pseudomonas sp. (S)-2-hydroxypropionic acid + chloride
-
 ?
(R)-2-chloropropionic acid + H2O
-
 Pseudomonas sp. 113 (S)-2-hydroxypropionic acid + chloride
-
 ?
(S)-2-chloropropionic acid + H2O
-
 Pseudomonas sp. (R)-2-hydroxypropionic acid + chloride
-
 ?
(S)-2-chloropropionic acid + H2O
-
 Pseudomonas sp. 113 (R)-2-hydroxypropionic acid + chloride
-
 ?
additional information the enzyme has a single common active site for both reactions on L- and D-enantiomers, the reaction mechanismm does not proceed via an ester intermediate and not via a nucleophilic aspartate attacking the C-atom of the substrate to displace the halo-atom on contrast to the (S)-2-haloacid dehalogenase, EC 3.8.1.2. In the (S,R)-2-haloacid dehalogenase, a water molecule directly atacks the substrate for halide displacement, structure-function relationship, overview Pseudomonas sp. ?
-
 ?
additional information the enzyme has a single common active site for both reactions on L- and D-enantiomers, the reaction mechanismm does not proceed via an ester intermediate and not via a nucleophilic aspartate attacking the C-atom of the substrate to displace the halo-atom on contrast to the (S)-2-haloacid dehalogenase, EC 3.8.1.2. In the (S,R)-2-haloacid dehalogenase, a water molecule directly atacks the substrate for halide displacement, structure-function relationship, overview Pseudomonas sp. 113 ?
-
 ?

Subunits

Subunits Comment Organism
More structure comparisons, overview Pseudomonas sp.

Synonyms

Synonyms Comment Organism
DL-2-haloacid dehalogenase
-
 Pseudomonas sp.
DL-DEX 113
-
 Pseudomonas sp.