Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.7.1.4 extracted from

  • Verhave, M.; Krasinski, S.D.; Christian, S.I.; Van Schaik, S.; Van Den Brink, G.R.; Doting, E.M.; Maas, S.M.; Wolthers, K.C.; Grand, R.J.; Montgomery, R.K.
    Regulatory regions in the rat lactase-phlorizin hydrolase gene that control cell-specific expression (2004), J. Pediatr. Gastroenterol. Nutr., 39, 275-285.
    View publication on PubMed
Search for more literature for 3.7.1.4

Application

Application Comment Organism
molecular biology cell specificty of LPH gene expression depends upon both positive and negative interactions among elements in the first 2kb of the LPH 5'-flanking region, generally positive activity between -74 and -37 bp, a cell-specific negative region between -210 and -95 bp, and additional elements further toward the 5' terminus that confer a highly cell-specific response in reporter activity, potential binding sites for various intestinal transcription factors, binding of HNF3beta at three sites is relevant to LPH expression Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
transient transfection of deletion constructs in both LPH-expressing Caco-2 and LPH-nonexpressing Hep-G2 cells, and in HeLa cells Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information deletions of the LPH 5' flanking sequence and fusion 5' to the human growth hormone reporter gene Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Synonyms

Synonyms Comment Organism
lactase-phlorizin hydrolase
-
 Rattus norvegicus
LPH
-
 Rattus norvegicus