Application | Comment | Organism |
---|---|---|
medicine | plays a role in hereditary tyrosinemia | Mus musculus |
medicine | plays a role in degradation pathway of phenylalanine and tyrosine | Mus musculus |
Crystallization (Comment) | Organism |
---|---|
- |
Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
A134D | - |
Mus musculus |
C193R | mutant may affect the active-site geometry | Mus musculus |
D233V | mutant | Mus musculus |
G158D | mutant may affect the active-site geometry | Mus musculus |
G158D | mutant may affect the active site by perturbing the FAH quarternary structure | Mus musculus |
G207D | mutant may affect the active-site geometry | Mus musculus |
G369V | mutant may affect the active-site geometry | Mus musculus |
N16I | mutant may disrupt activity by causing misfolding | Mus musculus |
P249T | mutant may affect the active-site geometry | Mus musculus |
P261L | mutant may cause general structural effects or misfolding by disrupting the hydrophobic core, the native mainchain conformation and/or important electrostatic interactions | Mus musculus |
P342L | mutant may cause general structural effects or misfolding by disrupting the hydrophobic core, the native mainchain conformation and/or important electrostatic interactions | Mus musculus |
S405H | mutant may cause general structural effects or misfolding by disrupting the hydrophobic core, the native mainchain conformation and/or important electrostatic interactions | Mus musculus |
V166G | mutant may affect the active-site geometry | Mus musculus |
W234G | mutant may affect the active-site geometry | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
46000 | - |
2 * 46000 | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-fumarylacetoacetate + H2O | Mus musculus | - |
acetoacetate + fumarate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-fumarylacetoacetate + H2O | - |
Mus musculus | acetoacetate + fumarate | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 46000 | Mus musculus |