Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Br- | - |
Sus scrofa | |
Cl- | enhancement of tubulin polymerization by Cl--induced blockade of intrinsic GTPase. GTPase activity of tubulin is lower (2/3-fold) in Cl--containing solutions than that in Cl--free solutions containing Br- or NO3- | Sus scrofa | |
NO3- | - |
Sus scrofa |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microtubule | - |
Sus scrofa | 5874 | - |
neurite | - |
Sus scrofa | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Sus scrofa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | Sus scrofa | - |
GDP + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Sus scrofa | - |
neuron | - |
Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | - |
Sus scrofa | GDP + phosphate | - |
? | |
additional information | efficiency of in vitro tubulin polymerization in solutions containing a non-hydrolyzable analogue of GTP, GpCpp, instead of GTP is much higher than that in the presence of GTP | Sus scrofa | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Sus scrofa |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Sus scrofa |
General Information | Comment | Organism |
---|---|---|
malfunction | enhancement of tubulin polymerization by Cl--induced blockade of intrinsic GTPase | Sus scrofa |
physiological function | a part of stimulatory effects of Cl- on in vitro tubulin polymerization is mediated via an inhibitory effect on GTPase activity of tubulin, although Cl- also regulates in vitro tubulin polymerization by factors other than an inhibitory effect on GTPase activity | Sus scrofa |