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Literature summary for 3.6.5.6 extracted from

  • Thakur, M.; Chakraborti, P.K.
    GTPase activity of mycobacterial FtsZ is impaired due to its transphosphorylation by the eukaryotic-type Ser/Thr kinase, PknA (2006), J. Biol. Chem., 281, 40107-40113.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
into the pUC19 vector, and in the pGEX-KG vector for expression in Escherichia coli BL21DE3 cells Escherichia coli
into the pUC19 vector, and in the pGEX-KG vector for expression in Escherichia coli BL21DE3 cells Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
additional information the phosphorylated protein shows hardly any activity Mycobacterium tuberculosis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.042
-
GTP
-
Escherichia coli
0.042
-
GTP
-
Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + H2O Escherichia coli
-
GDP + phosphate
-
ir
GTP + H2O Mycobacterium tuberculosis
-
GDP + phosphate
-
ir

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Mycobacterium tuberculosis
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein FtsZ is a substrate of PknA Escherichia coli
phosphoprotein FtsZ is a substrate of PknA Mycobacterium tuberculosis

Purification (Commentary)

Purification (Comment) Organism
using a glutathione-Sepharose affinity column Escherichia coli
using a glutathione-Sepharose affinity column Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
Escherichia coli GDP + phosphate
-
ir
GTP + H2O
-
Mycobacterium tuberculosis GDP + phosphate
-
ir

Subunits

Subunits Comment Organism
More FtsZ initiates Z-ring formation and congregates several other proteins to form a septosomal complex Escherichia coli
More FtsZ initiates Z-ring formation and congregates several other proteins to form a septosomal complex Mycobacterium tuberculosis

Synonyms

Synonyms Comment Organism
eFtsZ
-
Escherichia coli
FtsZ
-
Escherichia coli
FtsZ
-
Mycobacterium tuberculosis
mFtsZ
-
Mycobacterium tuberculosis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
GTPase activity assay Escherichia coli
37
-
GTPase activity assay Mycobacterium tuberculosis

pI Value

Organism Comment pI Value Maximum pI Value
Escherichia coli predicted pI-value
-
4.5