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Literature summary for 3.6.5.3 extracted from

  • Mohammad-Qureshi, S.S.; Jennings, M.D.; Pavitt, G.D.
    Clues to the mechanism of action of eIF2B, the guanine-nucleotide-exchange factor for translation initiation (2008), Biochem. Soc. Trans., 36, 658-664.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information phosphorylation Saccharomyces cerevisiae
additional information active in GTP-bound form, inactive in GDP-bound form Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
E569A lethal mutation Saccharomyces cerevisiae
E569D lethal mutation, reduced binding to subunit gamma of eIF2 Saccharomyces cerevisiae
E569K lethal mutation, reduced binding to subunit gamma of eIF2 Saccharomyces cerevisiae
E569Q lethal mutation, reduced binding to subunit gamma of eIF2 Saccharomyces cerevisiae
L568A cold sensitivity, defect on protein interaction Saccharomyces cerevisiae
additional information inherited mutations cause fatal brain disorder: childhood ataxia with central nervous system hypomyelination, leukoencephalopathy with vanishing white matter, eIF2B-related disorders Saccharomyces cerevisiae
additional information mutations in subunit beta destabilize interaction between eIF2, eIF1A, eIF3 and eIF5 Saccharomyces cerevisiae
S576N slow-growing, cold sensitivity, defect on protein interaction Saccharomyces cerevisiae
T552I slow-growing, cold sensitivity, defect on protein interaction Saccharomyces cerevisiae
W699A lethal mutation, weakens binding to subunit beta and gamma of eIF2, prevents nucleotide exchange Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
additional information subunit alpha, beta and delta of eIF2B down-regulates activity of the eIF2B catalytic subcomplex Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-
Saccharomyces cerevisiae P32501
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
Saccharomyces cerevisiae GDP + phosphate
-
?

Subunits

Subunits Comment Organism
heteropentamer alphabetagammadeltaepsilon Saccharomyces cerevisiae
trimer alphabetagamma Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
eIF 2
-
Saccharomyces cerevisiae
eIF2B
-
Saccharomyces cerevisiae
eIF5
-
Saccharomyces cerevisiae
eukaryotic initiation factor 2
-
Saccharomyces cerevisiae
GTPase-activating protein
-
Saccharomyces cerevisiae
guanine-nucleotide-exchange factor of eIF2
-
Saccharomyces cerevisiae