Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | phosphorylation | Saccharomyces cerevisiae | |
additional information | active in GTP-bound form, inactive in GDP-bound form | Saccharomyces cerevisiae |
Protein Variants | Comment | Organism |
---|---|---|
E569A | lethal mutation | Saccharomyces cerevisiae |
E569D | lethal mutation, reduced binding to subunit gamma of eIF2 | Saccharomyces cerevisiae |
E569K | lethal mutation, reduced binding to subunit gamma of eIF2 | Saccharomyces cerevisiae |
E569Q | lethal mutation, reduced binding to subunit gamma of eIF2 | Saccharomyces cerevisiae |
L568A | cold sensitivity, defect on protein interaction | Saccharomyces cerevisiae |
additional information | inherited mutations cause fatal brain disorder: childhood ataxia with central nervous system hypomyelination, leukoencephalopathy with vanishing white matter, eIF2B-related disorders | Saccharomyces cerevisiae |
additional information | mutations in subunit beta destabilize interaction between eIF2, eIF1A, eIF3 and eIF5 | Saccharomyces cerevisiae |
S576N | slow-growing, cold sensitivity, defect on protein interaction | Saccharomyces cerevisiae |
T552I | slow-growing, cold sensitivity, defect on protein interaction | Saccharomyces cerevisiae |
W699A | lethal mutation, weakens binding to subunit beta and gamma of eIF2, prevents nucleotide exchange | Saccharomyces cerevisiae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | subunit alpha, beta and delta of eIF2B down-regulates activity of the eIF2B catalytic subcomplex | Saccharomyces cerevisiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Saccharomyces cerevisiae | P32501 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | - |
Saccharomyces cerevisiae | GDP + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
heteropentamer | alphabetagammadeltaepsilon | Saccharomyces cerevisiae |
trimer | alphabetagamma | Saccharomyces cerevisiae |
Synonyms | Comment | Organism |
---|---|---|
eIF 2 | - |
Saccharomyces cerevisiae |
eIF2B | - |
Saccharomyces cerevisiae |
eIF5 | - |
Saccharomyces cerevisiae |
eukaryotic initiation factor 2 | - |
Saccharomyces cerevisiae |
GTPase-activating protein | - |
Saccharomyces cerevisiae |
guanine-nucleotide-exchange factor of eIF2 | - |
Saccharomyces cerevisiae |