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Literature summary for 3.6.5.3 extracted from

  • Mesters, J.R.; Potapov, A.P.; de Graaf, J.M.; Kraal, B.
    Synergism betweeen the GTPase activities of EF-Tu.GTP and EF-G.GTP on empty ribosomes. Elongation factors as stimulators of the ribosomal oscillation between two conformations (1994), J. Mol. Biol., 242, 644-654.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
streptomycin only EF-G Escherichia coli

Application

Application Comment Organism
medicine protein biosynthesis Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
pulvomycin
-
Escherichia coli
tetracyclin
-
Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + H2O Escherichia coli
-
GDP + phosphate
-
?
GTP + H2O Escherichia coli MRE 600
-
GDP + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
EF-Tu and EF-G
-
Escherichia coli MRE 600
-
EF-Tu and EF-G
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
Escherichia coli GDP + phosphate
-
?
GTP + H2O
-
Escherichia coli MRE 600 GDP + phosphate
-
?