Literature summary for 3.6.5.1 extracted from

Arshavsky, V.Y.; Dumke, C.L.; Zhu, Y.; Artemyev, N.O.; Skiba, N.P.; Hamm, H.E.; Bownds, M.D.
Regulation of transducin GTPase activity in bovine rod outer segments (1994), J. Biol. Chem., 269, 19882-19887.

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Activating Compound

Activating Compound	Comment	Organism	Structure
gamma-subunit of cGMP phosphodiesterase	accelerate GTP hydrolysis by transducin	Bos taurus
gamma-subunit of cGMP phosphodiesterase	the GTPase activating epitope is located within the C-terminal third of phosphodiesterase	Bos taurus
rhodopsin	transducin is activated by photoexcited rhodopsin which catalyzes the exchange of transducin-bound GDP for GTP and then stays active until bound GTP is hydrolyzed by the intrinsic GTPase activity	Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
GTP + H2O	Bos taurus	photoreceptor G protein	GDP + phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	photoreceptor G protein transducin	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
retina	outer rod segment	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GTP + H2O	photoreceptor G protein	Bos taurus	GDP + phosphate	-	?

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Release 2023.1 (January 2023)