Cloned (Comment) | Organism |
---|---|
gene At5g47040, DNA and amino acid sequence determination and analysis, isozyme LON2 is encoded by gene aberrant peroxisome morphology 10, apem10 | Arabidopsis thaliana |
Protein Variants | Comment | Organism |
---|---|---|
Q144stop | naturally occuring mutation, gene At5g47040 expression is sufficient to rescue the apem10 phenotype, overview | Arabidopsis thaliana |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
peroxisome | - |
Arabidopsis thaliana | 5777 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | O64948 | Lon protease homolog 2, peroxisomal; gene apem10 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
leaf | - |
Arabidopsis thaliana | - |
Synonyms | Comment | Organism |
---|---|---|
APEM10 | - |
Arabidopsis thaliana |
LON protease 2 | - |
Arabidopsis thaliana |
lon2 | - |
Arabidopsis thaliana |
peroxisomal protease LON2 | - |
Arabidopsis thaliana |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Arabidopsis thaliana |
General Information | Comment | Organism |
---|---|---|
malfunction | the Arabidopsis apem10 mutant displays accelerated peroxisome degradation and a dramatically reduces number of peroxisomes. LON2 deficiency causes enhanced peroxisome degradation by autophagy, and peroxisomal proteins accumulates in the cytosol due to a decrease in the number of peroxisomes. The loss of function of LON2 leads to accelerated autophagy, accumulation of electron-dense inclusions in the peroxisome matrix and a delay in the elimination of glyoxysomal enzymes during post-germinative growth. apem10 phenotype, overview | Arabidopsis thaliana |
metabolism | the enzyme is involved in LON2- and autophagy-dependent degradation pathways during the functional transition of peroxisomes, two hypothetical mechanisms proposed for the functional transition of glyoxysomes to leaf peroxisomes, modeling | Arabidopsis thaliana |
physiological function | LON2 is involved in the peroxisomal functional transition and basal quality control of peroxisomes. Chaperone and protease functions of LON protease 2 modulate the peroxisomal transition and degradation with autophagy. Proteolytic consequence of LON2 for the degradation of peroxisomal proteins, unnecessary proteins are eliminated by LON2- and autophagy-dependent degradation pathways during the functional transition of peroxisomes. LON2 plays dual roles as an ATP-dependent protease and a chaperone. The chaperone domain of LON2 is essential for the suppression of autophagy, whereas its peptidase domain interferes with this chaperone function, indicating that intramolecular modulation between the proteolysis and chaperone functions of LON2 regulates degradation of peroxisomes by autophagy | Arabidopsis thaliana |