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Literature summary for 3.6.4.7 extracted from

  • Shiozawa Kumik, S.K.; Goda Natsuk, G.N.; Shimizu Toshiyuk, S.T.; Mizuguchi Kenj, M.K.; Kondo Naom, K.N.; Shimozawa Nobuyuk, S.N.; Shirakawa Masahir, S.M.; Hiroaki Hidekaz, H.H.
    The common phospholipid-binding activity of the N-terminal domains of PEX1 and VCP/p97 (2006), FEBS J., 273, 4959-4971.
    View publication on PubMed
Search for more literature for 3.6.4.7

Application

Application Comment Organism
medicine autosomal recessive mutations in the PEX genes cause peroxisome biogenesis disorders, such as Zellweger syndrome, neonatal adrenoleukodystrophy and infantile Refsum disease Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
a GST fusion protein containing the PEX1 gene encoding residues 3-180, the N-terminal domain, in pGEX-4T3-PRESAT is constructed Mus musculus

Protein Variants

Protein Variants Comment Organism
K174A mutant, binds with approximately the same affinity and specificity as the wild-type protein Mus musculus
R135A mutant, the conserved arginine surrounded by hydrophobic residues is essential for lipid binding Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisomal membrane
-
 Mus musculus 5778
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Mus musculus
-
 ADP + phosphate
-
 ir

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
using glutathione Sepharose Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
 Mus musculus ADP + phosphate
-
 ir

Synonyms

Synonyms Comment Organism
Pex1
-
 Mus musculus