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Literature summary for 3.6.4.6 extracted from

  • Dalal, S.; Rosser, M.F.N.; Cyr, D.M.; Hanson, P.I.
    Distinct roles for the AAA ATPases NSF and p97 in the secretory pathway (2004), Mol. Biol. Cell, 15, 637-648.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.4.6

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Mus musculus
expression in U2OS TRex cells Cricetulus griseus

Protein Variants

Protein Variants Comment Organism
E305Q mutant assembles into oligomer like wild-type, similar ATPase activity as wild-type Mus musculus
E305Q/E578Q no ATPase activity Mus musculus
E329Q in contrast to wild-type NFS E329Q mutant is enriched on various structures throughout the cell and is only minimally released by saponin permeabilization Cricetulus griseus
E578Q mutant assembles into oligomer like wild-type, severely impaired ATPase activity Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Cricetulus griseus 5829
-
cytosol
-
 Mus musculus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Cricetulus griseus
-
 ADP + phosphate
-
 ?
ATP + H2O Mus musculus
-
 ADP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
-
-
-
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
 Cricetulus griseus ADP + phosphate
-
 ?
ATP + H2O
-
 Mus musculus ADP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
N-ethyl maleimide sensitive factor
-
 Cricetulus griseus
NSF
-
 Cricetulus griseus