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Literature summary for 3.6.4.13 extracted from

  • Chen, G.; Liu, C.H.; Zhou, L.; Krug, R.M.
    Cellular DDX21 RNA helicase inhibits influenza A virus replication but is counteracted by the viral NS1 protein (2014), Cell Host Microbe, 15, 484-493.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.4.13

Protein Variants

Protein Variants Comment Organism
additional information enzyme knockout using two DDX21 siRNAs Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme DDX21 inhibits influenza A virus replication. Enzyme DDX21 most likely binds viral PB1 protein in the cytoplasm, where protein PB1 is probably free of the other polymerase subunits, albeit transiently, before it forms a complex with viral protein PA that is imported into the nucleus ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NR30
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Calu-3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme DDX21 inhibits influenza A virus replication. Enzyme DDX21 most likely binds viral PB1 protein in the cytoplasm, where protein PB1 is probably free of the other polymerase subunits, albeit transiently, before it forms a complex with viral protein PA that is imported into the nucleus Homo sapiens ?
-
 ?
additional information the enzyme DDX21 binds to the RNA binding domain of viral NS1 protein, specifically to a region comprised of amino acids R37, R38, K41 and R44 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
DDX21
-
 Homo sapiens
DDX21 RNA helicase
-
 Homo sapiens

General Information

General Information Comment Organism
additional information influenza A virus likely uses the DDX21-NS1 interaction not only to overcome restriction but also to regulate the viral life cycle Homo sapiens
physiological function human host DDX21 RNA helicase restricts influenza A virus by binding PB1 protein and inhibiting polymerase assembly, resulting in reduced viral RNA and protein synthesis. Later during infection, the viral NS1 protein overcomes this restriction by binding to DDX21 and displacing PB1. DDX21 binds to a region of the NS1 N-terminal domain that also participates in other critical functions Homo sapiens