Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | p68 interacts with an intronic splicing activator, RNA binding motif protein 4 (RBM4), thereby stimulating tau exon 10 inclusion | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P17844 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | p68 interacts with an intronic splicing activator, RNA binding motif protein 4 (RBM4), thereby stimulating tau exon 10 inclusion | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DDX5 | - |
Homo sapiens |
RNA Helicase p68 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | using an RNA affinity pulldown-coupled mass spectrometry approach DDX5/RNA helicase p68 is identified as an activator of tau exon 10 splicing. p68 regulates tau exon 10 splicing by interacting with the stem-loop region, destabilizing the stem structure, and facilitating U1snRNP binding to this 5' splice site | Homo sapiens |