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Literature summary for 3.6.4.13 extracted from

  • Kar, A.; Fushimi, K.; Zhou, X.; Ray, P.; Shi, C.; Chen, X.; Liu, Z.; Chen, S.; Wu, J.Y.
    RNA helicase p68 (DDX5) regulates tau exon 10 splicing by modulating a stem-loop structure at the 5 splice site (2011), Mol. Cell. Biol., 31, 1812-1821.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens p68 interacts with an intronic splicing activator, RNA binding motif protein 4 (RBM4), thereby stimulating tau exon 10 inclusion ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens P17844
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information p68 interacts with an intronic splicing activator, RNA binding motif protein 4 (RBM4), thereby stimulating tau exon 10 inclusion Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
DDX5
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Homo sapiens
RNA Helicase p68
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Homo sapiens

General Information

General Information Comment Organism
physiological function using an RNA affinity pulldown-coupled mass spectrometry approach DDX5/RNA helicase p68 is identified as an activator of tau exon 10 splicing. p68 regulates tau exon 10 splicing by interacting with the stem-loop region, destabilizing the stem structure, and facilitating U1snRNP binding to this 5' splice site Homo sapiens