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Literature summary for 3.6.4.13 extracted from

  • Carter, C.L.; Lin, C.; Liu, C.Y.; Yang, L.; Liu, Z.R.
    Phosphorylated p68 RNA helicase activates Snail1 transcription by promoting HDAC1 dissociation from the Snail1 promoter (2010), Oncogene, 29, 5427-5436.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
Y593F expression of the mutant enzyme in SW620 cells leads to Snail repression, E-cadherin upregulation and vimentin repression Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation of p68 RNA helicase at Y593 upregulates transcription of the Snail1 gene Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
SW-480 cell
-
Homo sapiens
-
SW-620 cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
p68 RNA helicase
-
Homo sapiens

General Information

General Information Comment Organism
physiological function phosphorylation of p68 RNA helicase at Y593 upregulates transcription of the Snail1 gene. The phosphorylated p68 activates transcription of the Snail1 gene by promoting histone deacetylase dissociation from the Snail1 promoter. p68 interacts with the nuclear remodeling and deacetylation complex MBD3:Mi-2/NuRD. The DEAD-box RNA unwindase could potentially regulate gene expression by functioning as a protein displacer to modulate protein–protein interactions at the chromatin-remodeling complex Homo sapiens