Literature summary for 3.6.4.10 extracted from

Tupling, A.R.; Gramolini, A.O.; Duhamel, T.A.; Kondo, H.; Asahi, M.; Tsuchiya, S.C.; Borrelli, M.J.; Lepock, J.R.; Otsu, K.; Hori, M.; MacLennan, D.H.; Green, H.J.
HSP70 binds to the fast-twitch skeletal muscle sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA1a) and prevents thermal inactivation (2004), J. Biol. Chem., 279, 52382-52389.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O	HSP70 can bind to sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA1a) and, depending on the severity of heat stress, protect SERCA1a function by stabilizing the nucleotide binding N-domain	Homo sapiens	ADP + phosphate	-	?
ATP + H2O	HSP70 can bind to sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA1a) and, depending on the severity of heat stress, protect SERCA1a function by stabilizing the nucleotide binding N-domain	Rattus norvegicus	ADP + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
Hsp70	-	Homo sapiens
Hsp70	-	Rattus norvegicus

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Release 2023.1 (January 2023)