Literature summary for 3.6.1.9 extracted from

Cimpean, A.; Stefan, C.; Gijsbers, R.; Stalmans, W.; Bollen, M.
Substrate-specifying determinants of the nucleotide pyrophosphatases/phosphodiesterases NPP1 and NPP2 (2004), Biochem. J., 381, 71-77.

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Protein Variants

Protein Variants	Comment	Organism
H242L	60% decrease in enzymic acitivity	Mus musculus
H242L/V246A	60% decrease in enzymic acitivity	Mus musculus
additional information	chimera of enzyme catalytic domain fused to the N- and C-terminal domains of rat NPP2, a lysophospholipase D enzyme. Chimera is hyperactive in enzymic activity, but shows no lysophospholipase D activity. Second chimera of enzyme N- and/or C-terminal domains fused to the catalytic domain of NPP2 is completely inactive	Mus musculus
V246A	40% decrease in enzymic acitivity	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	P06802	recombinant enzyme	-

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Release 2023.1 (January 2023)