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Literature summary for 3.6.1.7 extracted from
- Acylphosphate phosphohydrolases (1995), Life Chem. Rep., 12, 271-301.
No PubMed abstract available
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| cDNA, erythrocyte isoenzyme | Homo sapiens |
| expression in Escherichia coli using pT7.7 expression vector | Homo sapiens |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| muscle enzyme, not suitable for X-ray diffraction | Equus caballus |
| muscular isoenzyme | Oryctolagus cuniculus |
| not suitable for X-ray diffraction | Sus scrofa |
| not suitable for X-ray diffraction | Oryctolagus cuniculus |
| skeletal muscle enzyme | Sus scrofa |
General Stability
| General Stability | Organism |
|---|---|
| 8 M urea denaturation is biphasic, being more rapid in the first min then slowing progressively | Equus caballus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Cl- | - |
Bos taurus |  |
| Cl- | - |
Cavia porcellus | |
| Cl- | - |
Equus caballus | |
| Cl- | - |
Gallus gallus | |
| Cl- | - |
Homo sapiens | |
| Cl- | - |
Meleagris gallopavo | |
| Hg2+ | - |
Gallus gallus | |
| Hg2+ | - |
Homo sapiens | |
| Orotic acid | - |
Equus caballus | |
| Orotic acid | - |
Rattus norvegicus | |
| phosphate | - |
Bos taurus | |
| phosphate | competitive inhibition | Cavia porcellus | |
| phosphate | competitive inhibition | Equus caballus | |
| phosphate | competitive inhibition; phosphate: competitive inhibition, muscular enzyme, native Ki: 2.29 mM, recombinant, expressed as fusion protein with glutathione S-transferase, Ki: 3.05 | Homo sapiens | |
| phosphate | competitive inhibition | Meleagris gallopavo | |
| phosphate | - |
Rattus norvegicus | |
| phosphate | - |
Sus scrofa | |
| sulfate | - |
Sus scrofa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetic data | Gallus gallus | |
| additional information | - |
additional information | kinetic data | Meleagris gallopavo | |
| additional information | - |
additional information | kinetic data | Cavia porcellus | |
| additional information | - |
additional information | kinetic data | Homo sapiens | |
| additional information | - |
additional information | kinetic data | Sus scrofa | |
| additional information | - |
additional information | kinetic data | Bos taurus | |
| additional information | - |
additional information | kinetic data | Oryctolagus cuniculus | |
| additional information | - |
additional information | kinetic data | Equus caballus | |
| 0.0000034 | - |
Ca2+-ATPase phosphoenzyme intermediate | erythrocyte isoenzyme, phosphorylated intermediate of erythrocyte membrane Ca2+-ATPase | Homo sapiens | |
| 0.000069 | - |
Na+/K+-ATPase phosphoenzyme intermediate | - |
Bos taurus | |
| 0.000147 | - |
Na+/K+-ATPase phosphoenzyme intermediate | - |
Homo sapiens | |
| 0.12 | - |
benzoyl phosphate | erythrocyte enzyme | Bos taurus | |
| 0.14 | - |
benzoyl phosphate | brain, erythrocyte enzyme | Equus caballus | |
| 0.15 | - |
benzoyl phosphate | erythrocyte enzyme | Homo sapiens | |
| 0.18 | - |
benzoyl phosphate | erythrocyte isoenzyme | Meleagris gallopavo | |
| 0.55 | - |
1,3-diphosphoglycerate | erythrocyte enzyme | Homo sapiens | |
| 0.62 | - |
1,3-diphosphoglycerate | skeletal muscle enzyme | Homo sapiens | |
| 0.7 | - |
benzoyl phosphate | muscular isoenzyme | Oryctolagus cuniculus | |
| 0.8 | - |
benzoyl phosphate | - |
Homo sapiens | |
| 0.8 | - |
benzoyl phosphate | muscular isoenzyme | Bos taurus | |
| 0.81 | - |
benzoyl phosphate | muscle enzyme | Equus caballus | |
| 0.81 | - |
benzoyl phosphate | skeletal muscle enzyme | Homo sapiens | |
| 0.85 | - |
benzoyl phosphate | - |
Homo sapiens | |
| 0.95 | - |
benzoyl phosphate | brain, muscular isoenzyme | Equus caballus | |
| 1 | - |
benzoyl phosphate | muscular isoenzyme | Meleagris gallopavo | |
| 2.9 | - |
acetyl phosphate | erythrocyte enzyme | Homo sapiens | |
| 4.2 | - |
Carbamoyl phosphate | skeletal muscle enzyme | Homo sapiens | |
| 5.42 | - |
Carbamoyl phosphate | erythrocyte enzyme | Homo sapiens | |
| 6.2 | - |
acetyl phosphate | skeletal muscle enzyme | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | cytosolic enzyme | Gallus gallus | 5737 | - |
| cytoplasm | cytosolic enzyme | Meleagris gallopavo | 5737 | - |
| cytoplasm | cytosolic enzyme | Cavia porcellus | 5737 | - |
| cytoplasm | cytosolic enzyme | Homo sapiens | 5737 | - |
| cytoplasm | cytosolic enzyme | Rattus norvegicus | 5737 | - |
| cytoplasm | cytosolic enzyme | Sus scrofa | 5737 | - |
| cytoplasm | cytosolic enzyme | Saccharomyces cerevisiae | 5737 | - |
| cytoplasm | cytosolic enzyme | Bos taurus | 5737 | - |
| cytoplasm | cytosolic enzyme | Oryctolagus cuniculus | 5737 | - |
| cytoplasm | cytosolic enzyme | Anas platyrhynchos | 5737 | - |
| cytoplasm | cytosolic enzyme | Equus caballus | 5737 | - |
| sarcoplasmic reticulum | - |
Equus caballus | 16529 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 11370 | - |
muscle, calculated from amino acid sequence | Equus caballus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1,3-diphosphoglycerate + H2O | Gallus gallus | - |
3-phosphoglycerate + phosphate | - |
? | |
| 1,3-diphosphoglycerate + H2O | Homo sapiens | - |
3-phosphoglycerate + phosphate | - |
? | |
| 1,3-diphosphoglycerate + H2O | Sus scrofa | - |
3-phosphoglycerate + phosphate | - |
? | |
| 1,3-diphosphoglycerate + H2O | Saccharomyces cerevisiae | - |
3-phosphoglycerate + phosphate | - |
? | |
| 1,3-diphosphoglycerate + H2O | Bos taurus | - |
3-phosphoglycerate + phosphate | - |
? | |
| 1,3-diphosphoglycerate + H2O | Oryctolagus cuniculus | - |
3-phosphoglycerate + phosphate | - |
? | |
| 1,3-diphosphoglycerate + H2O | Equus caballus | - |
3-phosphoglycerate + phosphate | - |
? | |
| carbamoyl phosphate + H2O | Sus scrofa | - |
carbamate + phosphate | - |
? | |
| carbamoyl phosphate + H2O | Equus caballus | - |
carbamate + phosphate | - |
? | |
| carbamoyl phosphate + H2O | Rattus norvegicus | acylphosphatase could have a function of controlling the intracellular levels of carbamoylphosphate by preventing the accumulation of this compound mainly in those tissues lacking the urea cycle enzymes. It could avoid the carbamylation of many proteins which results in modifications, inhibition of their functional properties | carbamate + phosphate | - |
? | |
| carbamoyl phosphate + H2O | Rattus norvegicus | role in pyrimidine biosynthesis | carbamate + phosphate | - |
? | |
| additional information | Homo sapiens | role of acylphosphatase in pathologic situations | ? | - |
? | |
| additional information | Homo sapiens | possible acyphosphatase involvement in the regulation of ion transport, and of calcium uptake in sarcoplasmic reticulum | ? | - |
? | |
| additional information | Gallus gallus | possible role of acylphosphatase in cell differentiation | ? | - |
? | |
| additional information | Homo sapiens | possible role of acylphosphatase in cell differentiation | ? | - |
? | |
| additional information | Gallus gallus | acylphosphatase isoenzymes are probably involved in membrane ion transport, and glycolysis control | ? | - |
? | |
| additional information | Meleagris gallopavo | acylphosphatase isoenzymes are probably involved in membrane ion transport, and glycolysis control | ? | - |
? | |
| additional information | Cavia porcellus | acylphosphatase isoenzymes are probably involved in membrane ion transport, and glycolysis control | ? | - |
? | |
| additional information | Homo sapiens | acylphosphatase isoenzymes are probably involved in membrane ion transport, and glycolysis control | ? | - |
? | |
| additional information | Rattus norvegicus | acylphosphatase isoenzymes are probably involved in membrane ion transport, and glycolysis control | ? | - |
? | |
| additional information | Sus scrofa | acylphosphatase isoenzymes are probably involved in membrane ion transport, and glycolysis control | ? | - |
? | |
| additional information | Saccharomyces cerevisiae | acylphosphatase isoenzymes are probably involved in membrane ion transport, and glycolysis control | ? | - |
? | |
| additional information | Bos taurus | acylphosphatase isoenzymes are probably involved in membrane ion transport, and glycolysis control | ? | - |
? | |
| additional information | Oryctolagus cuniculus | acylphosphatase isoenzymes are probably involved in membrane ion transport, and glycolysis control | ? | - |
? | |
| additional information | Anas platyrhynchos | acylphosphatase isoenzymes are probably involved in membrane ion transport, and glycolysis control | ? | - |
? | |
| additional information | Equus caballus | acylphosphatase isoenzymes are probably involved in membrane ion transport, and glycolysis control | ? | - |
? | |
| additional information | Homo sapiens | enzyme thought to participate in the regulation of glycolytic pathways and the synthesis of pyrimidine | ? | - |
? | |
| additional information | Oryctolagus cuniculus | enzyme thought to participate in the regulation of glycolytic pathways and the synthesis of pyrimidine | ? | - |
? | |
| additional information | Homo sapiens | acylphosphatase increases the rate of Na+,K+-dependent ATP hydrolysis, acylphosphatase significantly stimulates the rate of ATP driven Na+ transport into sarcolemma vesicles: accelerrated hydrolysis of the phosphoenzyme may result in an enhanced activity of heart sarcolemma Na+,K+ pump, suggesting a potential role of acylphosphatase in the control of this active transport system | ? | - |
? | |
| additional information | Bos taurus | acylphosphatase increases the rate of Na+,K+-dependent ATP hydrolysis, acylphosphatase significantly stimulates the rate of ATP driven Na+ transport into sarcolemma vesicles: accelerrated hydrolysis of the phosphoenzyme may result in an enhanced activity of heart sarcolemma Na+,K+ pump, suggesting a potential role of acylphosphatase in the control of this active transport system | ? | - |
? | |
| additional information | Equus caballus | possible physiological role for acylphosphatase activity may be regulation of metabolic pathways involving 1,3-diphosphoglycerate and carbamoyl phosphate, e.g. glycolytic pathway and pyrimidine biosynthesis, by its ability to hydrolyze these substrates | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Anas platyrhynchos | - |
- |
- |
| Bos taurus | - |
ox | - |
| Bos taurus | - |
bovine | - |
| Cavia porcellus | - |
guinea pig | - |
| Chondrichthyes | - |
small amounts | - |
| Equus caballus | - |
- |
- |
| Escherichia coli | - |
- |
- |
| Gallus gallus | - |
- |
- |
| Homo sapiens | - |
human | - |
| Meleagris gallopavo | - |
turkey | - |
| Oryctolagus cuniculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
| Sus scrofa | - |
- |
- |
| Vigna unguiculata | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| side-chain modification | skeletal muscle, acetylated at the NH2-terminus, Ac-Ala as the NH2-terminal residue | Rattus norvegicus |
| side-chain modification | erythrocyte isoenzyme, NH2-terminus is acetylated | Bos taurus |
| side-chain modification | muscular isoenzyme, acetylated at the N-terminus | Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Gallus gallus |
- |
Meleagris gallopavo |
- |
Cavia porcellus |
- |
Homo sapiens |
- |
Rattus norvegicus |
- |
Sus scrofa |
- |
Oryctolagus cuniculus |
- |
Anas platyrhynchos |
| brain | Bos taurus |
| muscle and liver | Equus caballus |
| ox | Bos taurus |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| an acylphosphate + H2O = a carboxylate + phosphate | reaction mechanism | Gallus gallus | |
| an acylphosphate + H2O = a carboxylate + phosphate | reaction mechanism | Homo sapiens | |
| an acylphosphate + H2O = a carboxylate + phosphate | reaction mechanism | Bos taurus | |
| an acylphosphate + H2O = a carboxylate + phosphate | catalytic mechanism | Gallus gallus | |
| an acylphosphate + H2O = a carboxylate + phosphate | catalytic mechanism | Homo sapiens |
Renatured (Commentary)
| Renatured (Comment) | Organism |
|---|---|
| renaturation after thermal denaturation, 65°C | Homo sapiens |
| renaturation after thermal denaturation, 65°C | Equus caballus |
| renaturation after treatment with urea | Homo sapiens |
| renaturation after treatment with urea | Equus caballus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Gallus gallus | - |
| brain | - |
Homo sapiens | - |
| brain | - |
Sus scrofa | - |
| brain | - |
Bos taurus | - |
| brain | - |
Equus caballus | - |
| duodenum | small amounts of muscular isoenzyme | Homo sapiens | - |
| duodenum | small amounts of muscular isoenzyme | Equus caballus | - |
| erythrocyte | - |
Gallus gallus | - |
| erythrocyte | - |
Homo sapiens | - |
| erythrocyte | - |
Bos taurus | - |
| heart | - |
Gallus gallus | - |
| heart | - |
Homo sapiens | - |
| heart | - |
Sus scrofa | - |
| heart | - |
Bos taurus | - |
| heart | - |
Equus caballus | - |
| intestine | small amounts of muscular isoenzyme | Homo sapiens | - |
| intestine | small amounts of muscular isoenzyme | Equus caballus | - |
| intestine | small intestine, erythrocyte isoenzyme | Homo sapiens | - |
| kidney | - |
Gallus gallus | - |
| kidney | small amounts of muscular isoenzyme | Homo sapiens | - |
| kidney | small amounts of muscular isoenzyme | Equus caballus | - |
| liver | - |
Gallus gallus | - |
| liver | - |
Rattus norvegicus | - |
| liver | small amounts of muscular isoenzyme | Homo sapiens | - |
| liver | small amounts of muscular isoenzyme | Equus caballus | - |
| liver | erythrocyte isoenzyme very low | Homo sapiens | - |
| liver | erythrocyte isoenzyme very low | Equus caballus | - |
| lung | erythrocyte isoenzyme | Homo sapiens | - |
| additional information | widely distributed in varying tissues | Gallus gallus | - |
| additional information | widely distributed in varying tissues | Meleagris gallopavo | - |
| additional information | widely distributed in varying tissues | Cavia porcellus | - |
| additional information | widely distributed in varying tissues | Homo sapiens | - |
| additional information | widely distributed in varying tissues | Rattus norvegicus | - |
| additional information | widely distributed in varying tissues | Sus scrofa | - |
| additional information | widely distributed in varying tissues | Bos taurus | - |
| additional information | widely distributed in varying tissues | Oryctolagus cuniculus | - |
| additional information | widely distributed in varying tissues | Anas platyrhynchos | - |
| additional information | widely distributed in varying tissues | Equus caballus | - |
| additional information | different distribution of each isoenzyme, erythrocyte and muscular enzyme, in different organs and tissues | Homo sapiens | - |
| additional information | different distribution of each isoenzyme, erythrocyte and muscular enzyme, in different organs and tissues | Equus caballus | - |
| muscle | skeletal muscle | Gallus gallus | - |
| muscle | skeletal muscle | Meleagris gallopavo | - |
| muscle | skeletal muscle | Cavia porcellus | - |
| muscle | skeletal muscle | Homo sapiens | - |
| muscle | skeletal muscle | Rattus norvegicus | - |
| muscle | skeletal muscle | Sus scrofa | - |
| muscle | skeletal muscle | Bos taurus | - |
| muscle | skeletal muscle | Oryctolagus cuniculus | - |
| muscle | skeletal muscle | Anas platyrhynchos | - |
| muscle | skeletal muscle | Equus caballus | - |
| muscle | erythrocyte isoenzyme very low in skeletal muscle | Homo sapiens | - |
| muscle | erythrocyte isoenzyme very low in skeletal muscle | Equus caballus | - |
| seed | - |
Vigna unguiculata | - |
| spleen | - |
Gallus gallus | - |
| spleen | small amounts of muscular isoenzyme | Homo sapiens | - |
| spleen | small amounts of muscular isoenzyme | Equus caballus | - |
| stomach | small amounts of muscular isoenzyme | Homo sapiens | - |
| stomach | small amounts of muscular isoenzyme | Equus caballus | - |
| stomach | erythrocyte isoenzyme very low | Homo sapiens | - |
| stomach | erythrocyte isoenzyme very low | Equus caballus | - |
| testis | - |
Sus scrofa | - |
| testis | common type enzyme | Bos taurus | - |
| testis | small amounts of muscular isoenzyme | Homo sapiens | - |
| testis | small amounts of muscular isoenzyme | Equus caballus | - |
| uterus | small amounts of muscular isoenzyme | Homo sapiens | - |
| uterus | small amounts of muscular isoenzyme | Equus caballus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 7 | - |
substrate carbamoyl phosphate, muscle isoenzyme | Homo sapiens |
| 22 | - |
substrate carbamoyl phosphate, erythrocyte isoenzyme | Homo sapiens |
| 33 | - |
substrate acetyl phosphate, muscle isoenzyme | Homo sapiens |
| 35 | - |
substrate acetyl phosphate, erythrocyte isoenzyme | Homo sapiens |
| 1570 | - |
substrate 1,3-diphosphoglycerate, muscle enzyme | Homo sapiens |
| 3500 | - |
- |
Cavia porcellus |
| 3500 | - |
- |
Equus caballus |
| 3500 | - |
muscular isoenzyme | Meleagris gallopavo |
| 3600 | - |
- |
Cavia porcellus |
| 3600 | - |
- |
Homo sapiens |
| 3600 | - |
muscle isoenzyme | Oryctolagus cuniculus |
| 3650 | - |
- |
Bos taurus |
| 3650 | - |
muscle enzyme | Homo sapiens |
| 3650 | - |
muscle enzyme | Equus caballus |
| 3700 | - |
muscle enzyme | Bos taurus |
| 3744 | - |
brain, muscle enzyme | Equus caballus |
| 5960 | - |
muscle enzyme | Gallus gallus |
| 6900 | - |
substrate 1,3-diphosphoglycerate, erythrocyte enzyme | Homo sapiens |
| 7000 | - |
- |
Homo sapiens |
| 7000 | - |
erythrocyte isoenzyme | Bos taurus |
| 7160 | - |
skeletal muscle, substrate benzoyl phosphate, 25°C | Sus scrofa |
| 7500 | - |
erythrocyte isoenzyme, substrate benzoyl phosphate, 25°C | Homo sapiens |
| 7500 | - |
muscle enzyme, SH form | Oryctolagus cuniculus |
| 8500 | - |
muscle, erythrocyte isoenzyme | Gallus gallus |
| 9000 | - |
erythrocyte isoenzyme | Meleagris gallopavo |
| 10800 | - |
testis, erythrocyte enzyme | Sus scrofa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (Ca2+-Mg2+)-ATPase phosphorylated intermediate + H2O | - |
Homo sapiens | ? | - |
? | |
| (Ca2+-Mg2+)-ATPase phosphorylated intermediate + H2O | - |
Bos taurus | ? | - |
? | |
| (Ca2+-Mg2+)-ATPase phosphorylated intermediate + H2O | - |
Equus caballus | ? | - |
? | |
| 1,3-diphosphoglycerate + H2O | - |
Gallus gallus | 3-phosphoglycerate + phosphate | - |
? | |
| 1,3-diphosphoglycerate + H2O | - |
Meleagris gallopavo | 3-phosphoglycerate + phosphate | - |
? | |
| 1,3-diphosphoglycerate + H2O | - |
Homo sapiens | 3-phosphoglycerate + phosphate | - |
? | |
| 1,3-diphosphoglycerate + H2O | - |
Rattus norvegicus | 3-phosphoglycerate + phosphate | - |
? | |
| 1,3-diphosphoglycerate + H2O | - |
Sus scrofa | 3-phosphoglycerate + phosphate | - |
? | |
| 1,3-diphosphoglycerate + H2O | - |
Saccharomyces cerevisiae | 3-phosphoglycerate + phosphate | - |
? | |
| 1,3-diphosphoglycerate + H2O | - |
Bos taurus | 3-phosphoglycerate + phosphate | - |
? | |
| 1,3-diphosphoglycerate + H2O | - |
Oryctolagus cuniculus | 3-phosphoglycerate + phosphate | - |
? | |
| 1,3-diphosphoglycerate + H2O | - |
Equus caballus | 3-phosphoglycerate + phosphate | - |
? | |
| acetyl phosphate + H2O | - |
Gallus gallus | acetate + phosphate | - |
? | |
| acetyl phosphate + H2O | - |
Cavia porcellus | acetate + phosphate | - |
? | |
| acetyl phosphate + H2O | - |
Homo sapiens | acetate + phosphate | - |
? | |
| acetyl phosphate + H2O | - |
Sus scrofa | acetate + phosphate | - |
? | |
| acetyl phosphate + H2O | - |
Bos taurus | acetate + phosphate | - |
? | |
| acetyl phosphate + H2O | - |
Oryctolagus cuniculus | acetate + phosphate | - |
? | |
| acetyl phosphate + H2O | - |
Equus caballus | acetate + phosphate | - |
? | |
| acylphosphate + H2O | hydrolysis of acylphosphates both synthetic and physiologically relevant | Gallus gallus | carboxylate + phosphate | - |
? | |
| acylphosphate + H2O | hydrolysis of acylphosphates both synthetic and physiologically relevant | Meleagris gallopavo | carboxylate + phosphate | - |
? | |
| acylphosphate + H2O | hydrolysis of acylphosphates both synthetic and physiologically relevant | Cavia porcellus | carboxylate + phosphate | - |
? | |
| acylphosphate + H2O | hydrolysis of acylphosphates both synthetic and physiologically relevant | Homo sapiens | carboxylate + phosphate | - |
? | |
| acylphosphate + H2O | hydrolysis of acylphosphates both synthetic and physiologically relevant | Rattus norvegicus | carboxylate + phosphate | - |
? | |
| acylphosphate + H2O | hydrolysis of acylphosphates both synthetic and physiologically relevant | Sus scrofa | carboxylate + phosphate | - |
? | |
| acylphosphate + H2O | hydrolysis of acylphosphates both synthetic and physiologically relevant | Saccharomyces cerevisiae | carboxylate + phosphate | - |
? | |
| acylphosphate + H2O | hydrolysis of acylphosphates both synthetic and physiologically relevant | Bos taurus | carboxylate + phosphate | - |
? | |
| acylphosphate + H2O | hydrolysis of acylphosphates both synthetic and physiologically relevant | Oryctolagus cuniculus | carboxylate + phosphate | - |
? | |
| acylphosphate + H2O | hydrolysis of acylphosphates both synthetic and physiologically relevant | Anas platyrhynchos | carboxylate + phosphate | - |
? | |
| acylphosphate + H2O | hydrolysis of acylphosphates both synthetic and physiologically relevant | Equus caballus | carboxylate + phosphate | - |
? | |
| acylphosphate + H2O | specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates | Gallus gallus | carboxylate + phosphate | - |
? | |
| acylphosphate + H2O | specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates | Meleagris gallopavo | carboxylate + phosphate | - |
? | |
| acylphosphate + H2O | specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates | Cavia porcellus | carboxylate + phosphate | - |
? | |
| acylphosphate + H2O | specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates | Escherichia coli | carboxylate + phosphate | - |
? | |
| acylphosphate + H2O | specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates | Homo sapiens | carboxylate + phosphate | - |
? | |
| acylphosphate + H2O | specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates | Rattus norvegicus | carboxylate + phosphate | - |
? | |
| acylphosphate + H2O | specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates | Sus scrofa | carboxylate + phosphate | - |
? | |
| acylphosphate + H2O | specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates | Saccharomyces cerevisiae | carboxylate + phosphate | - |
? | |
| acylphosphate + H2O | specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates | Bos taurus | carboxylate + phosphate | - |
? | |
| acylphosphate + H2O | specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates | Oryctolagus cuniculus | carboxylate + phosphate | - |
? | |
| acylphosphate + H2O | specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates | Anas platyrhynchos | carboxylate + phosphate | - |
? | |
| acylphosphate + H2O | specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates | Equus caballus | carboxylate + phosphate | - |
? | |
| acylphosphate + H2O | specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates | Vigna unguiculata | carboxylate + phosphate | - |
? | |
| acylphosphate + H2O | specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates | Chondrichthyes | carboxylate + phosphate | - |
? | |
| benzoyl phosphate + H2O | - |
Gallus gallus | benzoate + phosphate | - |
? | |
| benzoyl phosphate + H2O | - |
Meleagris gallopavo | benzoate + phosphate | - |
? | |
| benzoyl phosphate + H2O | - |
Cavia porcellus | benzoate + phosphate | - |
? | |
| benzoyl phosphate + H2O | - |
Homo sapiens | benzoate + phosphate | - |
? | |
| benzoyl phosphate + H2O | - |
Rattus norvegicus | benzoate + phosphate | - |
? | |
| benzoyl phosphate + H2O | - |
Sus scrofa | benzoate + phosphate | - |
? | |
| benzoyl phosphate + H2O | - |
Bos taurus | benzoate + phosphate | - |
? | |
| benzoyl phosphate + H2O | - |
Oryctolagus cuniculus | benzoate + phosphate | - |
? | |
| benzoyl phosphate + H2O | - |
Equus caballus | benzoate + phosphate | - |
? | |
| Ca2+-ATPase phosphoenzyme intermediate + H2O | - |
Homo sapiens | ? | - |
? | |
| carbamoyl phosphate + H2O | - |
Meleagris gallopavo | carbamate + phosphate | - |
? | |
| carbamoyl phosphate + H2O | - |
Homo sapiens | carbamate + phosphate | - |
? | |
| carbamoyl phosphate + H2O | - |
Rattus norvegicus | carbamate + phosphate | - |
? | |
| carbamoyl phosphate + H2O | - |
Sus scrofa | carbamate + phosphate | - |
? | |
| carbamoyl phosphate + H2O | - |
Bos taurus | carbamate + phosphate | - |
? | |
| carbamoyl phosphate + H2O | - |
Equus caballus | carbamate + phosphate | - |
? | |
| carbamoyl phosphate + H2O | acylphosphatase could have a function of controlling the intracellular levels of carbamoylphosphate by preventing the accumulation of this compound mainly in those tissues lacking the urea cycle enzymes. It could avoid the carbamylation of many proteins which results in modifications, inhibition of their functional properties | Rattus norvegicus | carbamate + phosphate | - |
? | |
| carbamoyl phosphate + H2O | role in pyrimidine biosynthesis | Rattus norvegicus | carbamate + phosphate | - |
? | |
| DNA + H2O | - |
Meleagris gallopavo | ? | - |
? | |
| DNA + H2O | - |
Homo sapiens | ? | - |
? | |
| DNA + H2O | - |
Bos taurus | ? | - |
? | |
| additional information | substrate specificity | Gallus gallus | ? | - |
? | |
| additional information | substrate specificity | Meleagris gallopavo | ? | - |
? | |
| additional information | substrate specificity | Homo sapiens | ? | - |
? | |
| additional information | substrate specificity | Sus scrofa | ? | - |
? | |
| additional information | substrate specificity | Bos taurus | ? | - |
? | |
| additional information | substrate specificity | Oryctolagus cuniculus | ? | - |
? | |
| additional information | substrate specificity | Equus caballus | ? | - |
? | |
| additional information | specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates | Gallus gallus | ? | - |
? | |
| additional information | specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates | Meleagris gallopavo | ? | - |
? | |
| additional information | specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates | Homo sapiens | ? | - |
? | |
| additional information | specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates | Sus scrofa | ? | - |
? | |
| additional information | specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates | Saccharomyces cerevisiae | ? | - |
? | |
| additional information | specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates | Bos taurus | ? | - |
? | |
| additional information | specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates | Oryctolagus cuniculus | ? | - |
? | |
| additional information | specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates | Equus caballus | ? | - |
? | |
| additional information | role of acylphosphatase in pathologic situations | Homo sapiens | ? | - |
? | |
| additional information | possible acyphosphatase involvement in the regulation of ion transport, and of calcium uptake in sarcoplasmic reticulum | Homo sapiens | ? | - |
? | |
| additional information | possible role of acylphosphatase in cell differentiation | Gallus gallus | ? | - |
? | |
| additional information | possible role of acylphosphatase in cell differentiation | Homo sapiens | ? | - |
? | |
| additional information | acylphosphatase isoenzymes are probably involved in membrane ion transport, and glycolysis control | Gallus gallus | ? | - |
? | |
| additional information | acylphosphatase isoenzymes are probably involved in membrane ion transport, and glycolysis control | Meleagris gallopavo | ? | - |
? | |
| additional information | acylphosphatase isoenzymes are probably involved in membrane ion transport, and glycolysis control | Cavia porcellus | ? | - |
? | |
| additional information | acylphosphatase isoenzymes are probably involved in membrane ion transport, and glycolysis control | Homo sapiens | ? | - |
? | |
| additional information | acylphosphatase isoenzymes are probably involved in membrane ion transport, and glycolysis control | Rattus norvegicus | ? | - |
? | |
| additional information | acylphosphatase isoenzymes are probably involved in membrane ion transport, and glycolysis control | Sus scrofa | ? | - |
? | |
| additional information | acylphosphatase isoenzymes are probably involved in membrane ion transport, and glycolysis control | Saccharomyces cerevisiae | ? | - |
? | |
| additional information | acylphosphatase isoenzymes are probably involved in membrane ion transport, and glycolysis control | Bos taurus | ? | - |
? | |
| additional information | acylphosphatase isoenzymes are probably involved in membrane ion transport, and glycolysis control | Oryctolagus cuniculus | ? | - |
? | |
| additional information | acylphosphatase isoenzymes are probably involved in membrane ion transport, and glycolysis control | Anas platyrhynchos | ? | - |
? | |
| additional information | acylphosphatase isoenzymes are probably involved in membrane ion transport, and glycolysis control | Equus caballus | ? | - |
? | |
| additional information | enzyme thought to participate in the regulation of glycolytic pathways and the synthesis of pyrimidine | Homo sapiens | ? | - |
? | |
| additional information | enzyme thought to participate in the regulation of glycolytic pathways and the synthesis of pyrimidine | Oryctolagus cuniculus | ? | - |
? | |
| additional information | acylphosphatase increases the rate of Na+,K+-dependent ATP hydrolysis, acylphosphatase significantly stimulates the rate of ATP driven Na+ transport into sarcolemma vesicles: accelerrated hydrolysis of the phosphoenzyme may result in an enhanced activity of heart sarcolemma Na+,K+ pump, suggesting a potential role of acylphosphatase in the control of this active transport system | Homo sapiens | ? | - |
? | |
| additional information | acylphosphatase increases the rate of Na+,K+-dependent ATP hydrolysis, acylphosphatase significantly stimulates the rate of ATP driven Na+ transport into sarcolemma vesicles: accelerrated hydrolysis of the phosphoenzyme may result in an enhanced activity of heart sarcolemma Na+,K+ pump, suggesting a potential role of acylphosphatase in the control of this active transport system | Bos taurus | ? | - |
? | |
| additional information | possible physiological role for acylphosphatase activity may be regulation of metabolic pathways involving 1,3-diphosphoglycerate and carbamoyl phosphate, e.g. glycolytic pathway and pyrimidine biosynthesis, by its ability to hydrolyze these substrates | Equus caballus | ? | - |
? | |
| Na+/K+-ATPase phosphoenzyme intermediate + H2O | - |
Homo sapiens | ? | - |
? | |
| Na+/K+-ATPase phosphoenzyme intermediate + H2O | - |
Bos taurus | ? | - |
? | |
| succinoyl phosphate + H2O | - |
Meleagris gallopavo | succinate + phosphate | - |
? | |
| succinoyl phosphate + H2O | - |
Homo sapiens | succinate + phosphate | - |
? | |
| succinoyl phosphate + H2O | - |
Bos taurus | succinate + phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | - |
Gallus gallus |
| monomer | - |
Meleagris gallopavo |
| monomer | - |
Rattus norvegicus |
| monomer | - |
Sus scrofa |
| monomer | - |
Bos taurus |
| monomer | - |
Oryctolagus cuniculus |
| monomer | monomeric alpha,beta protein | Homo sapiens |
| monomer | monomeric alpha,beta protein | Equus caballus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | two isoenzymes in all tissues, organs, and cell types checked: 1. muscular isoenzyme, IM, and 2. erythrocyte isoenzyme, IE, on the basis of the cell-type in which they are mostly represented and from which they are purified for the first time | Gallus gallus |
| More | two isoenzymes in all tissues, organs, and cell types checked: 1. muscular isoenzyme, IM, and 2. erythrocyte isoenzyme, IE, on the basis of the cell-type in which they are mostly represented and from which they are purified for the first time | Meleagris gallopavo |
| More | two isoenzymes in all tissues, organs, and cell types checked: 1. muscular isoenzyme, IM, and 2. erythrocyte isoenzyme, IE, on the basis of the cell-type in which they are mostly represented and from which they are purified for the first time | Homo sapiens |
| More | two isoenzymes in all tissues, organs, and cell types checked: 1. muscular isoenzyme, IM, and 2. erythrocyte isoenzyme, IE, on the basis of the cell-type in which they are mostly represented and from which they are purified for the first time | Rattus norvegicus |
| More | two isoenzymes in all tissues, organs, and cell types checked: 1. muscular isoenzyme, IM, and 2. erythrocyte isoenzyme, IE, on the basis of the cell-type in which they are mostly represented and from which they are purified for the first time | Sus scrofa |
| More | two isoenzymes in all tissues, organs, and cell types checked: 1. muscular isoenzyme, IM, and 2. erythrocyte isoenzyme, IE, on the basis of the cell-type in which they are mostly represented and from which they are purified for the first time | Bos taurus |
| More | two isoenzymes in all tissues, organs, and cell types checked: 1. muscular isoenzyme, IM, and 2. erythrocyte isoenzyme, IE, on the basis of the cell-type in which they are mostly represented and from which they are purified for the first time | Oryctolagus cuniculus |
| More | two isoenzymes in all tissues, organs, and cell types checked: 1. muscular isoenzyme, IM, and 2. erythrocyte isoenzyme, IE, on the basis of the cell-type in which they are mostly represented and from which they are purified for the first time | Anas platyrhynchos |
| More | two isoenzymes in all tissues, organs, and cell types checked: 1. muscular isoenzyme, IM, and 2. erythrocyte isoenzyme, IE, on the basis of the cell-type in which they are mostly represented and from which they are purified for the first time | Equus caballus |
| More | two isoenzymatic forms: one prevalent in skeletal and cardiac muscle named muscle type, the other in red blood cells named erythrocyte or common type, even if both isoforms are expressed in all tissues | Meleagris gallopavo |
| More | two isoenzymatic forms: one prevalent in skeletal and cardiac muscle named muscle type, the other in red blood cells named erythrocyte or common type, even if both isoforms are expressed in all tissues | Homo sapiens |
| More | two isoenzymatic forms: one prevalent in skeletal and cardiac muscle named muscle type, the other in red blood cells named erythrocyte or common type, even if both isoforms are expressed in all tissues | Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Gallus gallus |
| additional information | - |
- |
Meleagris gallopavo |
| additional information | - |
- |
Rattus norvegicus |
| additional information | - |
- |
Sus scrofa |
| additional information | - |
muscle, pI: 11.4 | Homo sapiens |
| additional information | - |
muscle, pI: 11.4 | Equus caballus |
| 4.8 | 5.8 | - |
Homo sapiens |
| 5.3 | - |
- |
Gallus gallus |
| 5.3 | - |
- |
Meleagris gallopavo |
| 5.3 | - |
- |
Cavia porcellus |
| 5.3 | - |
- |
Rattus norvegicus |
| 5.3 | - |
- |
Sus scrofa |
| 5.3 | - |
- |
Saccharomyces cerevisiae |
| 5.3 | - |
- |
Bos taurus |
| 5.3 | - |
- |
Oryctolagus cuniculus |
| 5.3 | - |
- |
Equus caballus |
| 5.3 | - |
skeletal muscle enzyme | Homo sapiens |
| 5.5 | - |
erythrocyte enzyme | Homo sapiens |
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Release 2023.1 (January 2023)
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